[[4-[3-[[1-[[[(1S)-3-amino-1-[[[3-(1-naphthalenyl)propyl]amino]carbonyl]-3-oxopropyl]amino]carbonyl]cyclohexyl]amino]-3-[(2S)-2-fluoro]oxopropyl]phenyl]methyl] bis(1,1-dimethylethyl) phosphonate

Base Information

Chemical Name:[[4-[3-[[1-[[[(1S)-3-amino-1-[[[3-(1-naphthalenyl)propyl]amino]carbonyl]-3-oxopropyl]amino]carbonyl]cyclohexyl]amino]-3-[(2S)-2-fluoro]oxopropyl]phenyl]methyl] bis(1,1-dimethylethyl) phosphonate
CAS No.:811451-60-2
Molecular Formula:C₄₂H₅₈FN₄O₇P
Molecular Weight:780.917
Hs Code.:

[[4-[3-[[1-[[[(1S)-3-amino-1-[[[3-(1-naphthalenyl)propyl]amino]carbonyl]-3-oxopropyl]amino]carbonyl]cyclohexyl]amino]-3-[(2S)-2-fluoro]oxopropyl]phenyl]methyl] bis(1,1-dimethylethyl) phosphonate

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Chemical Property of [[4-[3-[[1-[[[(1S)-3-amino-1-[[[3-(1-naphthalenyl)propyl]amino]carbonyl]-3-oxopropyl]amino]carbonyl]cyclohexyl]amino]-3-[(2S)-2-fluoro]oxopropyl]phenyl]methyl] bis(1,1-dimethylethyl) phosphonate

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Technology Process of [[4-[3-[[1-[[[(1S)-3-amino-1-[[[3-(1-naphthalenyl)propyl]amino]carbonyl]-3-oxopropyl]amino]carbonyl]cyclohexyl]amino]-3-[(2S)-2-fluoro]oxopropyl]phenyl]methyl] bis(1,1-dimethylethyl) phosphonate

There total 2 articles about [[4-[3-[[1-[[[(1S)-3-amino-1-[[[3-(1-naphthalenyl)propyl]amino]carbonyl]-3-oxopropyl]amino]carbonyl]cyclohexyl]amino]-3-[(2S)-2-fluoro]oxopropyl]phenyl]methyl] bis(1,1-dimethylethyl) phosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 491831-46-0
bis(1,1-dimethylethyl) [[4-[3-oxo-3-[(4S)-2-oxo-4-phenyl-3-oxazolidinyl]propyl]phenyl]methyl]phosphonate

: 811451-60-2
[[4-[3-[[1-[[[(1S)-3-amino-1-[[[3-(1-naphthalenyl)propyl]amino]carbonyl]-3-oxopropyl]amino]carbonyl]cyclohexyl]amino]-3-[(2S)-2-fluoro]oxopropyl]phenyl]methyl] bis(1,1-dimethylethyl) phosphonate

Guidance literature:: Multi-step reaction with 3 steps

1: 73 percent / N-fluorobenzenesulphonimide; sodium bis(trimethylsilyl)amide / tetrahydrofuran / -78 - 20 °C

2: hydrogen peroxide; lithium hydroxide / tetrahydrofuran; H₂O / 0 - 20 °C

3: 86 percent / 1-hydroxy-7-azabenzotriazole; EDCl*HCl / dimethylformamide / 0 - 20 °C

With lithium hydroxide; 1-hydroxy-7-aza-benzotriazole; dihydrogen peroxide; sodium hexamethyldisilazane; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-fluorobenzene sulfonamide; In tetrahydrofuran; water; N,N-dimethyl-formamide;
DOI:10.1081/SCC-200034770

Reference yield:

: 811451-59-9
bis(1,1-dimethylethyl) [[4-[(2S)-2-fluoro-3-oxo-3-[(4S)-2-oxo-4-phenyl-3-oxazolidinyl]propyl]phenyl]methyl]phosphonate

: 811451-60-2
[[4-[3-[[1-[[[(1S)-3-amino-1-[[[3-(1-naphthalenyl)propyl]amino]carbonyl]-3-oxopropyl]amino]carbonyl]cyclohexyl]amino]-3-[(2S)-2-fluoro]oxopropyl]phenyl]methyl] bis(1,1-dimethylethyl) phosphonate

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogen peroxide; lithium hydroxide / tetrahydrofuran; H₂O / 0 - 20 °C

2: 86 percent / 1-hydroxy-7-azabenzotriazole; EDCl*HCl / dimethylformamide / 0 - 20 °C

With lithium hydroxide; 1-hydroxy-7-aza-benzotriazole; dihydrogen peroxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; water; N,N-dimethyl-formamide;
DOI:10.1081/SCC-200034770