4-(2-methoxyphenyl)-2-(1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)quinoline-8-carbonitrile

Base Information

Chemical Name:4-(2-methoxyphenyl)-2-(1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)quinoline-8-carbonitrile
CAS No.:1355337-81-3
Molecular Formula:C₃₀H₂₀N₄O₃S
Molecular Weight:516.58
Hs Code.:

Synonyms:4-(2-methoxyphenyl)-2-(1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)quinoline-8-carbonitrile

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Chemical Property of 4-(2-methoxyphenyl)-2-(1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)quinoline-8-carbonitrile

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Technology Process of 4-(2-methoxyphenyl)-2-(1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)quinoline-8-carbonitrile

There total 2 articles about 4-(2-methoxyphenyl)-2-(1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)quinoline-8-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 767-91-9
1-ethynyl-2-methoxybenzene

: C₂₁H₁₄N₄O₂S

: 1355337-81-3
4-(2-methoxyphenyl)-2-(1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)quinoline-8-carbonitrile

Guidance literature:: With tin(ll) chloride; In acetonitrile; at 80 ℃; for 12h; regioselective reaction;
DOI:10.1021/jo202256z

Reference yield:

: 155819-08-2
1-(benzenesulfonyl)-1H-pyrrolo[2,3-b]pyridine-3-carboxaldehyde

: 1885-29-6
anthranilic acid nitrile

: 1355337-81-3
4-(2-methoxyphenyl)-2-(1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)quinoline-8-carbonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: tin(ll) chloride / acetonitrile / 0.17 h / 20 °C

2: tin(ll) chloride / acetonitrile / 12 h / 80 °C

With tin(ll) chloride; In acetonitrile; 2: Povarov reaction;
DOI:10.1021/jo202256z