N-(5-allyl-2-(2,4-difluorophenyl)-7,7-difluoro-6-(4-methoxyphenyl)-4,5,6,7-tetrahydro-2H-pyrazolo[4,3-c]pyridine-3-yl)-3,3-dimethylbutanamide

Base Information

• Chemical Name: N-(5-allyl-2-(2,4-difluorophenyl)-7,7-difluoro-6-(4-methoxyphenyl)-4,5,6,7-tetrahydro-2H-pyrazolo[4,3-c]pyridine-3-yl)-3,3-dimethylbutanamide
• CAS No.: 1451076-41-7
• Molecular Formula: C₂₈H₃₀F₄N₄O₂
• Molecular Weight: 530.565
• Mol file: 1451076-41-7.mol

Synonyms:N-(5-allyl-2-(2,4-difluorophenyl)-7,7-difluoro-6-(4-methoxyphenyl)-4,5,6,7-tetrahydro-2H-pyrazolo[4,3-c]pyridine-3-yl)-3,3-dimethylbutanamide

Chemical Property of N-(5-allyl-2-(2,4-difluorophenyl)-7,7-difluoro-6-(4-methoxyphenyl)-4,5,6,7-tetrahydro-2H-pyrazolo[4,3-c]pyridine-3-yl)-3,3-dimethylbutanamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(5-allyl-2-(2,4-difluorophenyl)-7,7-difluoro-6-(4-methoxyphenyl)-4,5,6,7-tetrahydro-2H-pyrazolo[4,3-c]pyridine-3-yl)-3,3-dimethylbutanamide

There total 4 articles about N-(5-allyl-2-(2,4-difluorophenyl)-7,7-difluoro-6-(4-methoxyphenyl)-4,5,6,7-tetrahydro-2H-pyrazolo[4,3-c]pyridine-3-yl)-3,3-dimethylbutanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

3,3-dimethylbutanoic acid chloride (7065-46-5) + 5-allyl-7,7-difluoro-2-(2,4-difluorophenyl)-6-(4-methoxyphenyl)-4,5,6,7-tetrahydro-2H-pyrazolo[4,3-c]pyridine-3-amine (1451076-36-0) → N-(5-allyl-2-(2,4-difluorophenyl)-7,7-difluoro-6-(4-methoxyphenyl)-4,5,6,7-tetrahydro-2H-pyrazolo[4,3-c]pyridine-3-yl)-3,3-dimethylbutanamide (1451076-41-7)

Guidance literature:

With pyridine; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1016/j.tetlet.2013.07.076

Reference yield:

3-[(prop-2-en-1-yl)amino]propanenitrile (34508-81-1) → N-(5-allyl-2-(2,4-difluorophenyl)-7,7-difluoro-6-(4-methoxyphenyl)-4,5,6,7-tetrahydro-2H-pyrazolo[4,3-c]pyridine-3-yl)-3,3-dimethylbutanamide (1451076-41-7)

Guidance literature:

Multi-step reaction with 5 steps

1.1: methanol / 20 °C / Inert atmosphere

2.1: zinc; chloro-trimethyl-silane / tetrahydrofuran / 0.17 h / Inert atmosphere

2.2: 12 h / 20 °C / Inert atmosphere

3.1: diisopropylamine; n-butyllithium / tetrahydrofuran; hexane / 13 h / -78 - 20 °C / Inert atmosphere

4.1: ethanol / Reflux; Inert atmosphere

5.1: pyridine / 0 - 20 °C / Inert atmosphere

With pyridine; n-butyllithium; chloro-trimethyl-silane; diisopropylamine; zinc; In tetrahydrofuran; methanol; ethanol; hexane; 2.1: |Mannich Aminomethylation / 3.1: |Dieckmann Condensation;

DOI:10.1016/j.tetlet.2013.07.076

Reference yield:

ethyl 3-(N-(2-cyanoethyl)allylamino)-2,2-difluoro-3-(4-methoxyphenyl)propanoate (1451076-34-8) → N-(5-allyl-2-(2,4-difluorophenyl)-7,7-difluoro-6-(4-methoxyphenyl)-4,5,6,7-tetrahydro-2H-pyrazolo[4,3-c]pyridine-3-yl)-3,3-dimethylbutanamide (1451076-41-7)

Guidance literature:

Multi-step reaction with 3 steps

1: diisopropylamine; n-butyllithium / tetrahydrofuran; hexane / 13 h / -78 - 20 °C / Inert atmosphere

2: ethanol / Reflux; Inert atmosphere

3: pyridine / 0 - 20 °C / Inert atmosphere

With pyridine; n-butyllithium; diisopropylamine; In tetrahydrofuran; ethanol; hexane; 1: |Dieckmann Condensation;

DOI:10.1016/j.tetlet.2013.07.076

upstream raw materials:

3,3-dimethylbutanoic acid chloride

5-allyl-7,7-difluoro-2-(2,4-difluorophenyl)-6-(4-methoxyphenyl)-4,5,6,7-tetrahydro-2H-pyrazolo[4,3-c]pyridine-3-amine

3-[(prop-2-en-1-yl)amino]propanenitrile

ethyl 3-(N-(2-cyanoethyl)allylamino)-2,2-difluoro-3-(4-methoxyphenyl)propanoate