Technology Process of tert-Butyl-[(Z)-(2R,3S,4S)-6-iodo-3-(4-methoxy-benzyloxy)-1,2,4-trimethyl-hex-5-enyloxy]-dimethyl-silane
There total 8 articles about tert-Butyl-[(Z)-(2R,3S,4S)-6-iodo-3-(4-methoxy-benzyloxy)-1,2,4-trimethyl-hex-5-enyloxy]-dimethyl-silane which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 90 percent / NaH
2: 1.) O3, 2.) Me2S
4: lutidine
5: 83 percent / HF*pyridine / tetrahydrofuran / 6 h / Ambient temperature
6: Dess-Martin periodinane / CH2Cl2 / 0.17 h / Ambient temperature
7: 1.) NaHMDS, 2.) HMPA / 1.) THF, RT, 20 min, 2.) THF, RT, 1 h
With
N,N,N,N,N,N-hexamethylphosphoric triamide; dimethylsulfide; lutidine; sodium hexamethyldisilazane; sodium hydride; Dess-Martin periodane; pyridine hydrogenfluoride; ozone;
In
tetrahydrofuran; dichloromethane;
DOI:10.1021/ja961374o
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 48percent aq. HBr / 0.5 h / Ambient temperature
2: 90 percent / NaH
3: 1.) O3, 2.) Me2S
5: lutidine
6: 83 percent / HF*pyridine / tetrahydrofuran / 6 h / Ambient temperature
7: Dess-Martin periodinane / CH2Cl2 / 0.17 h / Ambient temperature
8: 1.) NaHMDS, 2.) HMPA / 1.) THF, RT, 20 min, 2.) THF, RT, 1 h
With
N,N,N,N,N,N-hexamethylphosphoric triamide; dimethylsulfide; lutidine; hydrogen bromide; sodium hexamethyldisilazane; sodium hydride; Dess-Martin periodane; pyridine hydrogenfluoride; ozone;
In
tetrahydrofuran; dichloromethane;
DOI:10.1021/ja961374o
- Guidance literature:
-
Multi-step reaction with 4 steps
1: lutidine
2: 83 percent / HF*pyridine / tetrahydrofuran / 6 h / Ambient temperature
3: Dess-Martin periodinane / CH2Cl2 / 0.17 h / Ambient temperature
4: 1.) NaHMDS, 2.) HMPA / 1.) THF, RT, 20 min, 2.) THF, RT, 1 h
With
N,N,N,N,N,N-hexamethylphosphoric triamide; lutidine; sodium hexamethyldisilazane; Dess-Martin periodane; pyridine hydrogenfluoride;
In
tetrahydrofuran; dichloromethane;
DOI:10.1021/ja961374o
