(3R,4S)-4-methyl-5-[(4-methoxyphenyl)methoxy]-3-(phenylmethoxy)-1-pentene

Base Information

Chemical Name:(3R,4S)-4-methyl-5-[(4-methoxyphenyl)methoxy]-3-(phenylmethoxy)-1-pentene
CAS No.:321921-76-0
Molecular Formula:C₂₁H₂₆O₃
Molecular Weight:326.436
Hs Code.:

Synonyms:(3R,4S)-4-methyl-5-[(4-methoxyphenyl)methoxy]-3-(phenylmethoxy)-1-pentene

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Chemical Property of (3R,4S)-4-methyl-5-[(4-methoxyphenyl)methoxy]-3-(phenylmethoxy)-1-pentene

Chemical Property:

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Technology Process of (3R,4S)-4-methyl-5-[(4-methoxyphenyl)methoxy]-3-(phenylmethoxy)-1-pentene

There total 3 articles about (3R,4S)-4-methyl-5-[(4-methoxyphenyl)methoxy]-3-(phenylmethoxy)-1-pentene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 824-94-2
p-methoxybenzyl chloride

: 321921-75-9
(2R,3R)-2-methyl-3-phenylmethoxy-4-penten-1-ol

: 321921-76-0
(3R,4S)-4-methyl-5-[(4-methoxyphenyl)methoxy]-3-(phenylmethoxy)-1-pentene

Guidance literature:: (2R,3R)-2-methyl-3-phenylmethoxy-4-penten-1-ol; With potassium hydride; In tetrahydrofuran; at 0 ℃; for 0.5h;

p-methoxybenzyl chloride; With tetra-(n-butyl)ammonium iodide; In tetrahydrofuran; at 0 ℃; for 0.0833333h;
DOI:10.1016/S0040-4020(00)00804-8

Reference yield:

: 1125-88-8
benzaldehyde dimethyl acetal

: 321921-76-0
(3R,4S)-4-methyl-5-[(4-methoxyphenyl)methoxy]-3-(phenylmethoxy)-1-pentene

Guidance literature:: Multi-step reaction with 3 steps

1.1: 97 percent / CSA / dimethylformamide / 96 h

2.1: 81 percent / DIBAL / CH₂Cl₂ / 2 h / 0 °C

3.1: KH / tetrahydrofuran / 0.5 h / 0 °C

3.2: 100 percent / tetrabutylammonium iodide / tetrahydrofuran / 0.08 h / 0 °C

With camphor-10-sulfonic acid; potassium hydride; diisobutylaluminium hydride; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; 1.1: Cyclization / 2.1: Reduction / 3.1: Metallation / 3.2: Substitution;
DOI:10.1016/S0040-4020(00)00804-8

Reference yield:

: (4R,5S)-5-methyl-2-phenyl-4-vinyl-[1,3]-dioxane

: 321921-76-0
(3R,4S)-4-methyl-5-[(4-methoxyphenyl)methoxy]-3-(phenylmethoxy)-1-pentene

Guidance literature:: Multi-step reaction with 2 steps

1.1: 81 percent / DIBAL / CH₂Cl₂ / 2 h / 0 °C

2.1: KH / tetrahydrofuran / 0.5 h / 0 °C

2.2: 100 percent / tetrabutylammonium iodide / tetrahydrofuran / 0.08 h / 0 °C

With potassium hydride; diisobutylaluminium hydride; In tetrahydrofuran; dichloromethane; 1.1: Reduction / 2.1: Metallation / 2.2: Substitution;
DOI:10.1016/S0040-4020(00)00804-8