Technology Process of O6-Benzyl-N2,3-etheno-2'-deoxyguanosine
There total 8 articles about O6-Benzyl-N2,3-etheno-2'-deoxyguanosine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
tetrabutyl ammonium fluoride;
In
tetrahydrofuran;
for 0.5h;
Ambient temperature;
DOI:10.1021/jo00061a033
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 48.3 percent / triphenylphosphine, diethyl azodicarboxylate / dioxane / 48 h / 24 °C
2: 93 percent / NaOH / methanol / 48 h / Ambient temperature
3: 47.9 percent / aq. sodium acetate, aq. acetic acid, KI / ethanol; H2O / 30 h / 37 - 40 °C / pH=4.5
4: 89 percent / pyridine / 12 h
5: 50 percent / 4-(dimethylamino)pyridine / acetonitrile / 12 h / 24 °C
6: 65 percent / tributyltin hydride, azobisisobutyronitrile / toluene / 3 h / Heating
7: 98 percent / tetrabutylammonium fluoride / tetrahydrofuran / 0.5 h / Ambient temperature
With
pyridine; dmap; sodium hydroxide; 2,2'-azobis(isobutyronitrile); tetrabutyl ammonium fluoride; tri-n-butyl-tin hydride; sodium acetate; acetic acid; triphenylphosphine; potassium iodide; diethylazodicarboxylate;
In
tetrahydrofuran; 1,4-dioxane; methanol; ethanol; water; toluene; acetonitrile;
DOI:10.1021/jo00061a033
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 47.9 percent / aq. sodium acetate, aq. acetic acid, KI / ethanol; H2O / 30 h / 37 - 40 °C / pH=4.5
2: 89 percent / pyridine / 12 h
3: 50 percent / 4-(dimethylamino)pyridine / acetonitrile / 12 h / 24 °C
4: 65 percent / tributyltin hydride, azobisisobutyronitrile / toluene / 3 h / Heating
5: 98 percent / tetrabutylammonium fluoride / tetrahydrofuran / 0.5 h / Ambient temperature
With
pyridine; dmap; 2,2'-azobis(isobutyronitrile); tetrabutyl ammonium fluoride; tri-n-butyl-tin hydride; sodium acetate; acetic acid; potassium iodide;
In
tetrahydrofuran; ethanol; water; toluene; acetonitrile;
DOI:10.1021/jo00061a033