tert-butyl (2R)-2-[({7-(hydroxy)-4-[3-chloro-4-fluoroanilino]quinazolin-5-yl}oxy)methyl]pyrrolidine-1-carboxylate

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Chemical Name:tert-butyl (2R)-2-[({7-(hydroxy)-4-[3-chloro-4-fluoroanilino]quinazolin-5-yl}oxy)methyl]pyrrolidine-1-carboxylate
CAS No.:1384452-28-1
Molecular Formula:C₂₄H₂₆ClFN₄O₄
Molecular Weight:488.946
Hs Code.:

Synonyms:tert-butyl (2R)-2-[({7-(hydroxy)-4-[3-chloro-4-fluoroanilino]quinazolin-5-yl}oxy)methyl]pyrrolidine-1-carboxylate

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Chemical Property of tert-butyl (2R)-2-[({7-(hydroxy)-4-[3-chloro-4-fluoroanilino]quinazolin-5-yl}oxy)methyl]pyrrolidine-1-carboxylate

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Technology Process of tert-butyl (2R)-2-[({7-(hydroxy)-4-[3-chloro-4-fluoroanilino]quinazolin-5-yl}oxy)methyl]pyrrolidine-1-carboxylate

There total 1 articles about tert-butyl (2R)-2-[({7-(hydroxy)-4-[3-chloro-4-fluoroanilino]quinazolin-5-yl}oxy)methyl]pyrrolidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 791602-84-1
tert-butyl (2R)-2-[({7-(benzyloxy)-4-[3-chloro-4-fluoroanilino]quinazolin-5-yl}oxy)methyl]pyrrolidine-1-carboxylate

: 1384452-28-1
tert-butyl (2R)-2-[({7-(hydroxy)-4-[3-chloro-4-fluoroanilino]quinazolin-5-yl}oxy)methyl]pyrrolidine-1-carboxylate

Guidance literature:: With hydrogen; 5%-palladium/activated carbon; In ethanol; at 25 ℃; for 16h; under 3750.38 Torr;

Reference yield:

: 74-96-4
ethyl bromide

: 1384452-28-1
tert-butyl (2R)-2-[({7-(hydroxy)-4-[3-chloro-4-fluoroanilino]quinazolin-5-yl}oxy)methyl]pyrrolidine-1-carboxylate

: 791602-86-3
N-(3-chloro-4-fluorophenyl)-7-ethoxy-5-{[(2R)-pyrrolidin-2-yl]methoxy}quinazolin-4-amine

Guidance literature:: ethyl bromide; tert-butyl (2R)-2-[({7-(hydroxy)-4-[3-chloro-4-fluoroanilino]quinazolin-5-yl}oxy)methyl]pyrrolidine-1-carboxylate; With potassium carbonate; In ISOPROPYLAMIDE; at 20 - 40 ℃; for 16h;

With trifluoroacetic acid; In ISOPROPYLAMIDE; at 20 ℃; for 20h;