1-Methoxy-1,3-dimethyl-2-phenyl-3a,4,7,7a-tetrahydro-1H-4,7-methano-indene

Base Information

• Chemical Name: 1-Methoxy-1,3-dimethyl-2-phenyl-3a,4,7,7a-tetrahydro-1H-4,7-methano-indene
• CAS No.: 154385-32-7
• Molecular Formula: C₁₉H₂₂O
• Molecular Weight: 266.383
• Mol file: 154385-32-7.mol

Synonyms:1-Methoxy-1,3-dimethyl-2-phenyl-3a,4,7,7a-tetrahydro-1H-4,7-methano-indene

Chemical Property of 1-Methoxy-1,3-dimethyl-2-phenyl-3a,4,7,7a-tetrahydro-1H-4,7-methano-indene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-Methoxy-1,3-dimethyl-2-phenyl-3a,4,7,7a-tetrahydro-1H-4,7-methano-indene

There total 2 articles about 1-Methoxy-1,3-dimethyl-2-phenyl-3a,4,7,7a-tetrahydro-1H-4,7-methano-indene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-Methyl-2-phenyl-3a,4,7,7a-tetrahydro-4,7-methano-inden-1-one (154385-26-9) → 1-Methoxy-1,3-dimethyl-2-phenyl-3a,4,7,7a-tetrahydro-1H-4,7-methano-indene (154385-32-7)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrahydrofuran

2: 1.) NaH / 1.) DMF, 2.) DMF

With sodium hydride; In tetrahydrofuran;

DOI:10.1021/ja00084a074

Reference yield:

1,3-Dimethyl-2-phenyl-3a,4,7,7a-tetrahydro-1H-4,7-methano-inden-1-ol + methyl iodide (74-88-4) → 1-Methoxy-1,3-dimethyl-2-phenyl-3a,4,7,7a-tetrahydro-1H-4,7-methano-indene (154385-32-7)

Guidance literature:

With sodium hydride; Yield given. Multistep reaction; 1.) DMF, 2.) DMF;

DOI:10.1021/ja00084a074

Reference yield: 63.0%

1-Methoxy-1,3-dimethyl-2-phenyl-3a,4,7,7a-tetrahydro-1H-4,7-methano-indene (154385-32-7) → (2,5-Dimethyl-cyclopenta-1,4-dienyl)-benzene (154385-40-7)

Guidance literature:

With n-butyllithium; In tetrahydrofuran; for 3h; Ambient temperature;

DOI:10.1021/ja00084a074

upstream raw materials:

methyl iodide

3-Methyl-2-phenyl-3a,4,7,7a-tetrahydro-4,7-methano-inden-1-one

Downstream raw materials:

(2,5-Dimethyl-cyclopenta-1,4-dienyl)-benzene