methyl 2-((1r,4r)-4-(4-(1-(phenylcarbamoyl)-1H-indol-5-yl)phenyl)cyclohexyl)acetate

Base Information

Chemical Name:methyl 2-((1r,4r)-4-(4-(1-(phenylcarbamoyl)-1H-indol-5-yl)phenyl)cyclohexyl)acetate
CAS No.:1245708-23-9
Molecular Formula:C₃₀H₃₂N₂O₃
Molecular Weight:468.596
Hs Code.:

Synonyms:methyl 2-((1r,4r)-4-(4-(1-(phenylcarbamoyl)-1H-indol-5-yl)phenyl)cyclohexyl)acetate

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Chemical Property of methyl 2-((1r,4r)-4-(4-(1-(phenylcarbamoyl)-1H-indol-5-yl)phenyl)cyclohexyl)acetate

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Technology Process of methyl 2-((1r,4r)-4-(4-(1-(phenylcarbamoyl)-1H-indol-5-yl)phenyl)cyclohexyl)acetate

There total 7 articles about methyl 2-((1r,4r)-4-(4-(1-(phenylcarbamoyl)-1H-indol-5-yl)phenyl)cyclohexyl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 701232-69-1
methyl 2-((trans)-4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)cyclohexyl)acetate

: 1245708-12-6
5-bromo-N-phenyl-1H-indole-1-carboxamide

: 1245708-23-9
methyl 2-((1r,4r)-4-(4-(1-(phenylcarbamoyl)-1H-indol-5-yl)phenyl)cyclohexyl)acetate

Guidance literature:: With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate; In dichloromethane; water; isopropyl alcohol; at 80 ℃; for 10h; Inert atmosphere;
DOI:10.1021/ml400527n

Reference yield:

: 105640-07-1
4-(4-hydroxyphenyl)cyclohexan-1-one

: 1245708-23-9
methyl 2-((1r,4r)-4-(4-(1-(phenylcarbamoyl)-1H-indol-5-yl)phenyl)cyclohexyl)acetate

Guidance literature:: Multi-step reaction with 6 steps

1: sodium hydride / tetrahydrofuran; mineral oil / 2.83 h / 0 - 20 °C / Inert atmosphere

2: palladium 10% on activated carbon; hydrogen / ethyl acetate / 1810.07 Torr

3: ethyl acetate / Heating

4: triethylamine / dichloromethane / 5 h / 0 °C / Inert atmosphere

5: potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 17 h / 80 °C / Inert atmosphere

6: sodium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / dichloromethane; water; isopropyl alcohol / 10 h / 80 °C / Inert atmosphere

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; palladium 10% on activated carbon; hydrogen; potassium acetate; sodium hydride; sodium carbonate; triethylamine; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; ethyl acetate; isopropyl alcohol; mineral oil;
DOI:10.1021/ml400527n

Reference yield:

: 701232-66-8
[4-(4-hydroxyphenyl)cyclohexylidene]acetic acid methyl ester

: 1245708-23-9
methyl 2-((1r,4r)-4-(4-(1-(phenylcarbamoyl)-1H-indol-5-yl)phenyl)cyclohexyl)acetate

Guidance literature:: Multi-step reaction with 5 steps

1: palladium 10% on activated carbon; hydrogen / ethyl acetate / 1810.07 Torr

2: ethyl acetate / Heating

3: triethylamine / dichloromethane / 5 h / 0 °C / Inert atmosphere

4: potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 17 h / 80 °C / Inert atmosphere

5: sodium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / dichloromethane; water; isopropyl alcohol / 10 h / 80 °C / Inert atmosphere

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; palladium 10% on activated carbon; hydrogen; potassium acetate; sodium carbonate; triethylamine; In 1,4-dioxane; dichloromethane; water; ethyl acetate; isopropyl alcohol;
DOI:10.1021/ml400527n