3-Sulfino-DL-valine

Base Information

• Chemical Name: 3-Sulfino-DL-valine
• CAS No.: 98462-04-5
• Molecular Formula: C₅H₁₁NO₄S
• Molecular Weight: 181.213
• Mol file: 98462-04-5.mol

Synonyms:2-amino-3-methyl-3-sulfinobutanoic acid

Chemical Property of 3-Sulfino-DL-valine

Chemical Property:

• Melting Point: 177-179°C (dec.)
• Boiling Point: 429.7±55.0 °C(Predicted)
• PKA: 2.36±0.12(Predicted)
• Density: 1.551±0.06 g/cm3(Predicted)
• Storage Temp.: Refrigerator, under inert atmosphere
• Solubility.: DMSO (Slightly, Heated), Methanol (Sparingly)

Purity/Quality:

99.90% ^*data from raw suppliers

3-Sulfino-DL-valine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 3-Sulfino-DL-valine is an impurity of the semi-synthetic β-lactamase inhibitor Sulbactam (S699185).

Technology Process of 3-Sulfino-DL-valine

There total 3 articles about 3-Sulfino-DL-valine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

sodium sulbactam (69388-84-7) → 3-oxopropanoic acid (926-61-4) + 2-amino-3-methyl-3-sulfinobutanoic acid (98462-04-5)

Guidance literature:

With borate buffer; at 65 ℃; for 1.5h;

DOI:10.1248/cpb.33.2035

Reference yield:

DL-Penicillamin (52-66-4) → α-amino-β-sulfo-isovaleric acid (3427-01-8) + 2-amino-3-methyl-3-sulfinobutanoic acid (98462-04-5)

Guidance literature:

With CrOO⁽²⁺⁾; In isopropyl alcohol; at 25 ℃; Further Variations:; Temperatures; ionic strength; initial concentrations; Kinetics; Thermodynamic data;

DOI:10.1021/jp9809336

Reference yield:

sodium sulbactam (1219196-30-1) → 2-amino-3-methyl-3-sulfinobutanoic acid (98462-04-5)

Guidance literature:

In water; at 35 - 65 ℃; Kinetics; Thermodynamic data; Arrhenius parameters; effect of pH and catalytic effect of buffer salts;

DOI:10.1248/cpb.33.2461

upstream raw materials:

sodium sulbactam

sodium sulbactam

DL-Penicillamin

Refernces

• 1、 Perez-Benito, Joaquin F.,Arias, Conchita. "Kinetics and mechanism of the reactions of superoxochromium(III) ion with biological thiols". . p. 5837 - 5845. Retrieved 2007/10/03.