1-acetyl-2-methoxycarbonyl-5,5-dimethyl-3-(p-nitrobenzyloxycarbonylaminoethylthio)-2-pyrroline

Base Information

Chemical Name:1-acetyl-2-methoxycarbonyl-5,5-dimethyl-3-(p-nitrobenzyloxycarbonylaminoethylthio)-2-pyrroline
CAS No.:96246-66-1
Molecular Formula:C₂₀H₂₅N₃O₇S
Molecular Weight:451.5
Hs Code.:

Synonyms:1-acetyl-2-methoxycarbonyl-5,5-dimethyl-3-(p-nitrobenzyloxycarbonylaminoethylthio)-2-pyrroline

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Chemical Property of 1-acetyl-2-methoxycarbonyl-5,5-dimethyl-3-(p-nitrobenzyloxycarbonylaminoethylthio)-2-pyrroline

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Technology Process of 1-acetyl-2-methoxycarbonyl-5,5-dimethyl-3-(p-nitrobenzyloxycarbonylaminoethylthio)-2-pyrroline

There total 5 articles about 1-acetyl-2-methoxycarbonyl-5,5-dimethyl-3-(p-nitrobenzyloxycarbonylaminoethylthio)-2-pyrroline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 65750-59-6
2-(4-nitrobenzyloxycarbonylamino)ethanethiol

: 105804-87-3
1-acetyl-2-methoxycarbonyl-5,5-dimethyl-3-diphenoxylphosphoryloxy-2-pyrroline

: 96246-66-1
1-acetyl-2-methoxycarbonyl-5,5-dimethyl-3-(p-nitrobenzyloxycarbonylaminoethylthio)-2-pyrroline

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; for 24h; under nitrogen;
DOI:10.1248/cpb.33.5190

Reference yield: 3.0%

: 1-acetyl-2-methoxycarbonyl-5,5-dimethyl-3-<(2-p-nitrobenzyloxycarbonylaminoethyl)methoxysulfonio>-2-pyrroline tetrafluoroborate

: 105804-91-9
1-acetyl-2-methoxycarbonyl-5,5-dimethyl-3-<2-(p-nitrobenzyloxycarbonylamino)ethylsulfinyl>-2-pyrroline

: 96246-66-1
1-acetyl-2-methoxycarbonyl-5,5-dimethyl-3-(p-nitrobenzyloxycarbonylaminoethylthio)-2-pyrroline

: 105804-96-4
1-acetyl-5,5-dimethyl-2-methoxycarbonyl-3-<1-methoxy-2-(p-nitrobenzyloxycarbonylamino)ethylthio>-2-pyrroline

Guidance literature:: With 1,8-diazabicyclo[5.4.0]undec-7-ene; In dimethylsulfoxide-d6; chloroform-d1; for 0.25h; Ambient temperature;
DOI:10.1248/cpb.33.5190

Reference yield:

: 105804-84-0
methyl 3-((2-methoxy-2-oxoethyl)amino)-3-methylbutanoate

: 96246-66-1
1-acetyl-2-methoxycarbonyl-5,5-dimethyl-3-(p-nitrobenzyloxycarbonylaminoethylthio)-2-pyrroline

Guidance literature:: Multi-step reaction with 4 steps

1: 87 percent / triethylamine / CH₂Cl₂ / 17 h / Ambient temperature

2: 53 percent / tert-BuOK / toluene / 0-5 degree C for 1 h, then room temperatura for 3 h

3: 7.70 g / diisopropylethylamine / acetonitrile / 17 h / Ambient temperature

4: 71 percent / diisopropylethylamine / dimethylformamide / 24 h / under nitrogen

With potassium tert-butylate; triethylamine; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide; toluene; acetonitrile;
DOI:10.1248/cpb.33.5190