1H-Pyrrole-2-carboxylic acid, 1-acetyl-2,5-dihydro-2-hydroxy-5,5-dimethyl-3-[[2-[[[(4-nitrophenyl)meth oxy]carbonyl]amino]ethyl]thio]-, methyl ester

Base Information

Chemical Name:1H-Pyrrole-2-carboxylic acid, 1-acetyl-2,5-dihydro-2-hydroxy-5,5-dimethyl-3-[[2-[[[(4-nitrophenyl)meth oxy]carbonyl]amino]ethyl]thio]-, methyl ester
CAS No.:105804-90-8
Molecular Formula:C₂₀H₂₅N₃O₈S
Molecular Weight:467.5
Hs Code.:

1H-Pyrrole-2-carboxylic acid,
1-acetyl-2,5-dihydro-2-hydroxy-5,5-dimethyl-3-[[2-[[[(4-nitrophenyl)meth
oxy]carbonyl]amino]ethyl]thio]-, methyl ester

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1H-Pyrrole-2-carboxylic acid, 1-acetyl-2,5-dihydro-2-hydroxy-5,5-dimethyl-3-[[2-[[[(4-nitrophenyl)meth oxy]carbonyl]amino]ethyl]thio]-, methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 1H-Pyrrole-2-carboxylic acid, 1-acetyl-2,5-dihydro-2-hydroxy-5,5-dimethyl-3-[[2-[[[(4-nitrophenyl)meth oxy]carbonyl]amino]ethyl]thio]-, methyl ester

There total 8 articles about 1H-Pyrrole-2-carboxylic acid, 1-acetyl-2,5-dihydro-2-hydroxy-5,5-dimethyl-3-[[2-[[[(4-nitrophenyl)meth oxy]carbonyl]amino]ethyl]thio]-, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 27.0%

: 105804-91-9
1-acetyl-2-methoxycarbonyl-5,5-dimethyl-3-<2-(p-nitrobenzyloxycarbonylamino)ethylsulfinyl>-2-pyrroline

: 105804-92-0
2-methoxycarbonyl-5,5-dimethyl-3-(p-nitrobenzyloxycarbonylaminoethylthio)-5H-pyrrole

: 105804-93-1
5-acetyl-4a-methoxycarbonyl-6,6-dimethyl-4-(p-nitrobenzyloxycarbonyl)-2,3,4,4a,5,6-hexahydropyrrolo<3.2-b><1,4>thiazine

: 105804-90-8
1-acetyl-2-hydroxy-2-methoxycarbonyl-5,5-dimethyl-3-(p-nitrobenzyloxycarbonylaminoethylthio)-3-pyrroline

Guidance literature:: With 2,4,6-trimethyl-pyridine; acetic anhydride; trifluoroacetic anhydride; for 45h; Ambient temperature;
DOI:10.1248/cpb.33.5190

Reference yield: 8.0%

: 96246-66-1
1-acetyl-2-methoxycarbonyl-5,5-dimethyl-3-(p-nitrobenzyloxycarbonylaminoethylthio)-2-pyrroline

: 105804-91-9
1-acetyl-2-methoxycarbonyl-5,5-dimethyl-3-<2-(p-nitrobenzyloxycarbonylamino)ethylsulfinyl>-2-pyrroline

: 105804-90-8
1-acetyl-2-hydroxy-2-methoxycarbonyl-5,5-dimethyl-3-(p-nitrobenzyloxycarbonylaminoethylthio)-3-pyrroline

Guidance literature:: With tert-butylhypochlorite; In dichloromethane; at 0 ℃; for 0.5h;
DOI:10.1248/cpb.33.5190

Reference yield:

: 65750-59-6
2-(4-nitrobenzyloxycarbonylamino)ethanethiol

: 105804-90-8
1-acetyl-2-hydroxy-2-methoxycarbonyl-5,5-dimethyl-3-(p-nitrobenzyloxycarbonylaminoethylthio)-3-pyrroline

Guidance literature:: Multi-step reaction with 3 steps

1: 71 percent / diisopropylethylamine / dimethylformamide / 24 h / under nitrogen

2: 76 percent / m-chloroperoxybenzoic acid / CH₂Cl₂ / 1 h / 0 °C

3: 25 percent / (CF₃CO)2O, 2,4,6-collidine / CH₂Cl₂ / 0.5 h / 0 °C

With 2,4,6-trimethyl-pyridine; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic anhydride; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1248/cpb.33.5190