Benzyl-[(E)-(R)-1-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-3-phenyl-allyl]-amine

Base Information

Chemical Name:Benzyl-[(E)-(R)-1-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-3-phenyl-allyl]-amine
CAS No.:872728-67-1
Molecular Formula:C₂₁H₂₅NO₂
Molecular Weight:323.435
Hs Code.:

Synonyms:Benzyl-[(E)-(R)-1-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-3-phenyl-allyl]-amine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Benzyl-[(E)-(R)-1-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-3-phenyl-allyl]-amine

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Technology Process of Benzyl-[(E)-(R)-1-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-3-phenyl-allyl]-amine

There total 1 articles about Benzyl-[(E)-(R)-1-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-3-phenyl-allyl]-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 27846-25-9
1-phenyl-2-(phenylsulfonyl)ethane

: 131319-74-9
(R)-2,3-di-O-isoproylideneglyceraldehyde N-benzylimine

: 3-benzenesulfonyl-2-methyl-4-phenyl-butan-2-ol

: 872728-67-1
Benzyl-[(E)-(R)-1-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-3-phenyl-allyl]-amine

: [2-Benzenesulfonyl-1-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-3-phenyl-propyl]-benzyl-amine

Guidance literature:: With n-butyllithium; In tetrahydrofuran; at -78 - 0 ℃; for 5h;
DOI:10.1016/j.tet.2005.09.046

Reference yield: 48.0%

: 872728-67-1
Benzyl-[(E)-(R)-1-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-3-phenyl-allyl]-amine

: 24424-99-5
di-tert-butyl dicarbonate

: (S)-2,2-Dimethyl-4-((E)-3-phenyl-propenyl)-[1,3]dioxolane

: 872728-70-6
(1R,4'S)-N-tert-butoxycarbonyl-1-(2',2'-dimethyl-[1',3']-dioxolan-4'-yl)-3-phenylpropylamine

Guidance literature:: With hydrogen; palladium dihydroxide; In ethyl acetate; at 20 ℃; for 24h; atmospheric pressure;
DOI:10.1016/j.tet.2005.09.046

Reference yield:

: 872728-67-1
Benzyl-[(E)-(R)-1-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-3-phenyl-allyl]-amine

: 100564-78-1,108524-68-1,142926-43-0,82732-07-8
(2R)-(tert-butoxycarbonylamino)-4-phenylbutanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 48 percent / H₂ / Pd(OH)2 / ethyl acetate / 24 h / 20 °C / atmospheric pressure

2: 83 percent / CF₃COOH / methanol; H₂O / 7 h / 20 °C

3: 71 percent / NaIO₄ / RuCl₃ / acetonitrile; CCl₄; H₂O / 1 h / 20 °C

With sodium periodate; hydrogen; trifluoroacetic acid; ruthenium trichloride; palladium dihydroxide; In methanol; tetrachloromethane; water; ethyl acetate; acetonitrile;
DOI:10.1016/j.tet.2005.09.046