1,4,9-Triazaspiro[5.5]undecane,9-methyl-(9CI)

Base Information

• Chemical Name: 1,4,9-Triazaspiro[5.5]undecane,9-methyl-(9CI)
• CAS No.: 90703-73-4
• Molecular Formula: C₉H₁₉N₃
• Molecular Weight: 169.27
• Mol file: 90703-73-4.mol

Synonyms:1,4,9-Triazaspiro[5.5]undecane,9-methyl-(9CI);9-METHYL-1,4,9-TRIAZASPIRO[5.5]UNDECANE

Chemical Property of 1,4,9-Triazaspiro[5.5]undecane,9-methyl-(9CI)

Chemical Property:

• PSA: 27.30000
• LogP: 0.23910

Purity/Quality:

97% ^*data from raw suppliers

9-methyl-1,4,9-Triazaspiro[5.5]undecane 97.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1,4,9-Triazaspiro[5.5]undecane,9-methyl-(9CI)

There total 3 articles about 1,4,9-Triazaspiro[5.5]undecane,9-methyl-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

9-methyl-1,4,9-triazaspiro<5,5>undec-4-ene (111725-48-5) → 9-methyl-1,4,9-triazaspiro<5,5>undecane (90703-73-4)

Guidance literature:

With hydrogen; nickel; In tert-butyl alcohol; at 90 ℃; for 9h; under 82506.6 Torr;

DOI:10.1007/BF00474359

Reference yield:

N-methyl-piperidine-4-carboxaldehyde (50675-21-3) → 9-methyl-1,4,9-triazaspiro<5,5>undecane (90703-73-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 96 percent / Br₂ / acetic acid / 1.5 h / 20 °C

2: 47 percent / K₂CO₃ / acetonitrile; methanol; H₂O / stirring 6h (temp. below 20 deg C) and left 2 days

3: 80 percent / H₂ / Raney Ni / 2-methyl-propan-2-ol / 9 h / 90 °C / 82506.6 Torr

With hydrogen; bromine; potassium carbonate; nickel; In methanol; water; acetic acid; acetonitrile; tert-butyl alcohol;

DOI:10.1007/BF00474359

Reference yield:

1-methyl-4-bromopiperidine-4-carboxaldehyde hydrobromide (111725-47-4) → 9-methyl-1,4,9-triazaspiro<5,5>undecane (90703-73-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 47 percent / K₂CO₃ / acetonitrile; methanol; H₂O / stirring 6h (temp. below 20 deg C) and left 2 days

2: 80 percent / H₂ / Raney Ni / 2-methyl-propan-2-ol / 9 h / 90 °C / 82506.6 Torr

With hydrogen; potassium carbonate; nickel; In methanol; water; acetonitrile; tert-butyl alcohol;

DOI:10.1007/BF00474359

upstream raw materials:

9-methyl-1,4,9-triazaspiro<5,5>undec-4-ene

N-methyl-piperidine-4-carboxaldehyde

1-methyl-4-bromopiperidine-4-carboxaldehyde hydrobromide