1-(4-(4-methoxyphenyl)thiazol-2-yl)-3-methylindeno[1,2-c]pyrazol-4(1H)-one

Base Information

• Chemical Name: 1-(4-(4-methoxyphenyl)thiazol-2-yl)-3-methylindeno[1,2-c]pyrazol-4(1H)-one
• CAS No.: 1609240-27-8
• Molecular Formula: C₂₁H₁₅N₃O₂S
• Molecular Weight: 373.435

Synonyms:1-(4-(4-methoxyphenyl)thiazol-2-yl)-3-methylindeno[1,2-c]pyrazol-4(1H)-one

Chemical Property of 1-(4-(4-methoxyphenyl)thiazol-2-yl)-3-methylindeno[1,2-c]pyrazol-4(1H)-one

Chemical Property:

Purity/Quality:

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Technology Process of 1-(4-(4-methoxyphenyl)thiazol-2-yl)-3-methylindeno[1,2-c]pyrazol-4(1H)-one

There total 5 articles about 1-(4-(4-methoxyphenyl)thiazol-2-yl)-3-methylindeno[1,2-c]pyrazol-4(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

2-(1-(2-(4-(4-methoxyphenyl)thiazol-2-yl)hydrazono)ethyl)-1H-indene-1,3(2H)-dione (1609240-19-8) → 1-(4-(4-methoxyphenyl)thiazol-2-yl)-3-methylindeno[1,2-c]pyrazol-4(1H)-one (1609240-27-8)

Guidance literature:

With acetic acid; In ethanol; for 5h; Reflux;

DOI:10.1002/jhet.1081

Reference yield:

2-acetyl-indan-1,3-dione (1133-72-8) → 1-(4-(4-methoxyphenyl)thiazol-2-yl)-3-methylindeno[1,2-c]pyrazol-4(1H)-one (1609240-27-8)

Guidance literature:

Multi-step reaction with 2 steps

1: ethanol / Reflux

2: acetic acid / ethanol / 5 h / Reflux

With acetic acid; In ethanol;

DOI:10.1002/jhet.1081

Reference yield:

2-hydrazino-4-(4-methoxy-phenyl)-thiazole (4871-25-4) → 1-(4-(4-methoxyphenyl)thiazol-2-yl)-3-methylindeno[1,2-c]pyrazol-4(1H)-one (1609240-27-8)

Guidance literature:

Multi-step reaction with 2 steps

1: ethanol / Reflux

2: acetic acid / ethanol / 5 h / Reflux

With acetic acid; In ethanol;

DOI:10.1002/jhet.1081

upstream raw materials:

2-acetyl-indan-1,3-dione

C₁₂H₁₁N₃O₂S

2-Bromo-4'-methoxyacetophenone

2-hydrazino-4-(4-methoxy-phenyl)-thiazole

Downstream raw materials:

4-(4'-methoxyphenyl)-2-(3-methylindeno[1,2-c]pyrazol-1(4H)-yl)thiazole

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