C₂₄H₂₄FN₇O₃

Base Information

• Chemical Name: C₂₄H₂₄FN₇O₃
• CAS No.: 1431871-14-5
• Molecular Formula: C₂₄H₂₄FN₇O₃
• Molecular Weight: 477.498
• Mol file: 1431871-14-5.mol

Synonyms:C₂₄H₂₄FN₇O₃

Chemical Property of C₂₄H₂₄FN₇O₃

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₄H₂₄FN₇O₃

There total 9 articles about C₂₄H₂₄FN₇O₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

C19H17FN6O2 (1431873-03-8) + <(2R)-5-oxopyrrolidin-2-yl>methyl 4-methylbenzenesulfonate (128899-31-0) → C24H24FN7O3 (1431871-14-5) + C24H24FN7O3 (1431870-94-8)

Guidance literature:

C₁₉H₁₇FN₆O₂; With sodium hydride; In N,N-dimethyl-formamide; at 5 ℃; for 0.5h; Inert atmosphere;

<(2R)-5-oxopyrrolidin-2-yl>methyl 4-methylbenzenesulfonate; In N,N-dimethyl-formamide; at 5 - 20 ℃; Inert atmosphere;

Reference yield:

C7H4BrN3O (1431872-97-7) → C24H24FN7O3 (1431871-14-5) + C24H24FN7O3 (1431870-94-8)

Guidance literature:

Multi-step reaction with 4 steps

1.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / 1,2-dimethoxyethane; water / 100 °C / Inert atmosphere

2.1: N,N-dimethyl-formamide; trichlorophosphate / 1,2-dichloro-ethane / 3 h / 80 °C

3.1: hydrogenchloride / 1,4-dioxane / 100 °C

4.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 5 °C / Inert atmosphere

4.2: 5 - 20 °C / Inert atmosphere

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydride; sodium carbonate; N,N-dimethyl-formamide; trichlorophosphate; In 1,4-dioxane; 1,2-dimethoxyethane; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide;

Reference yield:

C8H8ClN3O2 (1431872-96-6) → C24H24FN7O3 (1431871-14-5) + C24H24FN7O3 (1431870-94-8)

Guidance literature:

Multi-step reaction with 5 steps

1.1: hydrogen bromide; acetic acid / 3 h / 40 - 50 °C

2.1: N,N-dimethyl-formamide; trichlorophosphate / 1,2-dichloro-ethane / 3 h / 80 °C

3.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / 1,2-dimethoxyethane; water / 2 h / Inert atmosphere; Reflux

4.1: hydrogenchloride / 1,4-dioxane / 100 °C

5.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 5 °C / Inert atmosphere

5.2: 5 - 20 °C / Inert atmosphere

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; hydrogen bromide; sodium hydride; sodium carbonate; acetic acid; N,N-dimethyl-formamide; trichlorophosphate; In 1,4-dioxane; 1,2-dimethoxyethane; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide;

upstream raw materials:

C₇H₄BrN₃O

C₁₁H₉N₅O

C₁₁H₈ClN₅

6-chloropyridine-2,3-diamine

Downstream raw materials:

C₂₆H₂₈FN₇O₄