2-{(2S,6S,8S,10R,13S)-10-[2-(4-Methoxy-benzyloxy)-ethyl]-13-methyl-13-triethylsilanyloxy-1,7,9-trioxa-dispiro[5.1.5.2]pentadec-2-yl}-ethanol

Base Information

Chemical Name:2-{(2S,6S,8S,10R,13S)-10-[2-(4-Methoxy-benzyloxy)-ethyl]-13-methyl-13-triethylsilanyloxy-1,7,9-trioxa-dispiro[5.1.5.2]pentadec-2-yl}-ethanol
CAS No.:236427-82-0
Molecular Formula:C₃₁H₅₂O₇Si
Molecular Weight:564.835
Hs Code.:

Synonyms:2-{(2S,6S,8S,10R,13S)-10-[2-(4-Methoxy-benzyloxy)-ethyl]-13-methyl-13-triethylsilanyloxy-1,7,9-trioxa-dispiro[5.1.5.2]pentadec-2-yl}-ethanol

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Chemical Property of 2-{(2S,6S,8S,10R,13S)-10-[2-(4-Methoxy-benzyloxy)-ethyl]-13-methyl-13-triethylsilanyloxy-1,7,9-trioxa-dispiro[5.1.5.2]pentadec-2-yl}-ethanol

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Technology Process of 2-{(2S,6S,8S,10R,13S)-10-[2-(4-Methoxy-benzyloxy)-ethyl]-13-methyl-13-triethylsilanyloxy-1,7,9-trioxa-dispiro[5.1.5.2]pentadec-2-yl}-ethanol

There total 3 articles about 2-{(2S,6S,8S,10R,13S)-10-[2-(4-Methoxy-benzyloxy)-ethyl]-13-methyl-13-triethylsilanyloxy-1,7,9-trioxa-dispiro[5.1.5.2]pentadec-2-yl}-ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 236427-81-9
{(2R,5S,6S,8S,10S)-10-(2-Benzyloxy-ethyl)-2-[2-(4-methoxy-benzyloxy)-ethyl]-5-methyl-1,7,9-trioxa-dispiro[5.1.5.2]pentadec-5-yloxy}-triethyl-silane

: 236427-82-0
2-{(2S,6S,8S,10R,13S)-10-[2-(4-Methoxy-benzyloxy)-ethyl]-13-methyl-13-triethylsilanyloxy-1,7,9-trioxa-dispiro[5.1.5.2]pentadec-2-yl}-ethanol

Guidance literature:: With hydrogen; Raney Ni (W₂); In ethanol; for 4h; Ambient temperature;
DOI:10.1055/s-1999-2689

Reference yield:

: 79271-56-0
triethylsilyl trifluoromethyl sulfonate

: 236427-82-0
2-{(2S,6S,8S,10R,13S)-10-[2-(4-Methoxy-benzyloxy)-ethyl]-13-methyl-13-triethylsilanyloxy-1,7,9-trioxa-dispiro[5.1.5.2]pentadec-2-yl}-ethanol

Guidance literature:: Multi-step reaction with 2 steps

1: 95 percent / 2,6-lutidine / CH₂Cl₂ / 0.25 h / 0 °C

2: 81 percent / H₂ / Raney Ni (W₂) / ethanol / 4 h / Ambient temperature

With 2,6-dimethylpyridine; hydrogen; Raney Ni (W₂); In ethanol; dichloromethane;
DOI:10.1055/s-1999-2689

Reference yield:

: (2R,5S,6S,8S,10S)-10-(2-Benzyloxy-ethyl)-2-[2-(4-methoxy-benzyloxy)-ethyl]-5-methyl-1,7,9-trioxa-dispiro[5.1.5.2]pentadecan-5-ol

: 236427-82-0
2-{(2S,6S,8S,10R,13S)-10-[2-(4-Methoxy-benzyloxy)-ethyl]-13-methyl-13-triethylsilanyloxy-1,7,9-trioxa-dispiro[5.1.5.2]pentadec-2-yl}-ethanol

Guidance literature:: Multi-step reaction with 2 steps

1: 95 percent / 2,6-lutidine / CH₂Cl₂ / 0.25 h / 0 °C

2: 81 percent / H₂ / Raney Ni (W₂) / ethanol / 4 h / Ambient temperature

With 2,6-dimethylpyridine; hydrogen; Raney Ni (W₂); In ethanol; dichloromethane;
DOI:10.1055/s-1999-2689