{(2R,5S,6S,8S,10S)-10-(2-Benzyloxy-ethyl)-2-[2-(4-methoxy-benzyloxy)-ethyl]-5-methyl-1,7,9-trioxa-dispiro[5.1.5.2]pentadec-5-yloxy}-triethyl-silane

Base Information

Chemical Name:{(2R,5S,6S,8S,10S)-10-(2-Benzyloxy-ethyl)-2-[2-(4-methoxy-benzyloxy)-ethyl]-5-methyl-1,7,9-trioxa-dispiro[5.1.5.2]pentadec-5-yloxy}-triethyl-silane
CAS No.:236427-81-9
Molecular Formula:C₃₈H₅₈O₇Si
Molecular Weight:654.96
Hs Code.:

Synonyms:{(2R,5S,6S,8S,10S)-10-(2-Benzyloxy-ethyl)-2-[2-(4-methoxy-benzyloxy)-ethyl]-5-methyl-1,7,9-trioxa-dispiro[5.1.5.2]pentadec-5-yloxy}-triethyl-silane

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Chemical Property of {(2R,5S,6S,8S,10S)-10-(2-Benzyloxy-ethyl)-2-[2-(4-methoxy-benzyloxy)-ethyl]-5-methyl-1,7,9-trioxa-dispiro[5.1.5.2]pentadec-5-yloxy}-triethyl-silane

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Technology Process of {(2R,5S,6S,8S,10S)-10-(2-Benzyloxy-ethyl)-2-[2-(4-methoxy-benzyloxy)-ethyl]-5-methyl-1,7,9-trioxa-dispiro[5.1.5.2]pentadec-5-yloxy}-triethyl-silane

There total 1 articles about {(2R,5S,6S,8S,10S)-10-(2-Benzyloxy-ethyl)-2-[2-(4-methoxy-benzyloxy)-ethyl]-5-methyl-1,7,9-trioxa-dispiro[5.1.5.2]pentadec-5-yloxy}-triethyl-silane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 79271-56-0
triethylsilyl trifluoromethyl sulfonate

: (2R,5S,6S,8S,10S)-10-(2-Benzyloxy-ethyl)-2-[2-(4-methoxy-benzyloxy)-ethyl]-5-methyl-1,7,9-trioxa-dispiro[5.1.5.2]pentadecan-5-ol

: 236427-81-9
{(2R,5S,6S,8S,10S)-10-(2-Benzyloxy-ethyl)-2-[2-(4-methoxy-benzyloxy)-ethyl]-5-methyl-1,7,9-trioxa-dispiro[5.1.5.2]pentadec-5-yloxy}-triethyl-silane

Guidance literature:: With 2,6-dimethylpyridine; In dichloromethane; at 0 ℃; for 0.25h;
DOI:10.1055/s-1999-2689

Reference yield: 81.0%

: 236427-81-9
{(2R,5S,6S,8S,10S)-10-(2-Benzyloxy-ethyl)-2-[2-(4-methoxy-benzyloxy)-ethyl]-5-methyl-1,7,9-trioxa-dispiro[5.1.5.2]pentadec-5-yloxy}-triethyl-silane

: 236427-82-0
2-{(2S,6S,8S,10R,13S)-10-[2-(4-Methoxy-benzyloxy)-ethyl]-13-methyl-13-triethylsilanyloxy-1,7,9-trioxa-dispiro[5.1.5.2]pentadec-2-yl}-ethanol

Guidance literature:: With hydrogen; Raney Ni (W₂); In ethanol; for 4h; Ambient temperature;
DOI:10.1055/s-1999-2689

Reference yield:

: 236427-81-9
{(2R,5S,6S,8S,10S)-10-(2-Benzyloxy-ethyl)-2-[2-(4-methoxy-benzyloxy)-ethyl]-5-methyl-1,7,9-trioxa-dispiro[5.1.5.2]pentadec-5-yloxy}-triethyl-silane

: 10-[7-benzyloxymethyl-2-(tert-butyl-dimethyl-silanyloxy)-3-methyl-6,8-dioxa-bicyclo[3.2.1]oct-5-ylmethyl]-5-(tert-butyl-dimethyl-silanyloxy)-2-[2-(4-methoxy-benzyloxy)-ethyl]-5-methyl-1,7,9-trioxa-dispiro[5.1.5.2]pentadecane

Guidance literature:: Multi-step reaction with 8 steps

1: 81 percent / H₂ / Raney Ni (W₂) / ethanol / 4 h / Ambient temperature

2: 100 percent / Dess-Martin periodinane / CH₂Cl₂ / 5 h / Ambient temperature

3: 1.) BuLi / 1.) THF, -78 deg C, 30 min, 2.) -78 deg C, 1.5 h

4: Dess-Martin periodinane / CH₂Cl₂ / 3 h / Ambient temperature

5: SmI₂ / tetrahydrofuran; methanol / 1 h / -95 - -80 °C

6: Zn-Cu couple, NH₄Cl / methanol / 0.17 h / Ambient temperature

7: 60 percent / HF, H₂O / acetonitrile; tetrahydrofuran / 11 h / Ambient temperature

8: 34 percent / 2,6-lutidine / CH₂Cl₂ / 20 h / Ambient temperature

With 2,6-dimethylpyridine; n-butyllithium; samarium diiodide; hydrogen fluoride; water; hydrogen; copper; ammonium chloride; Dess-Martin periodane; zinc; Raney Ni (W₂); In tetrahydrofuran; methanol; ethanol; dichloromethane; acetonitrile;
DOI:10.1055/s-1999-2689