2-benzyl-6-bromo-N-(2-(dimethylamino)ethyl)-1-oxo-1,2-dihydroisoquinoline-4-carboxamide

Base Information

Chemical Name:2-benzyl-6-bromo-N-(2-(dimethylamino)ethyl)-1-oxo-1,2-dihydroisoquinoline-4-carboxamide
CAS No.:1070294-38-0
Molecular Formula:C₂₁H₂₂BrN₃O₂
Molecular Weight:428.329
Hs Code.:

Synonyms:2-benzyl-6-bromo-N-(2-(dimethylamino)ethyl)-1-oxo-1,2-dihydroisoquinoline-4-carboxamide

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Chemical Property of 2-benzyl-6-bromo-N-(2-(dimethylamino)ethyl)-1-oxo-1,2-dihydroisoquinoline-4-carboxamide

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Technology Process of 2-benzyl-6-bromo-N-(2-(dimethylamino)ethyl)-1-oxo-1,2-dihydroisoquinoline-4-carboxamide

There total 7 articles about 2-benzyl-6-bromo-N-(2-(dimethylamino)ethyl)-1-oxo-1,2-dihydroisoquinoline-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1070294-36-8
2-benzyl-6-bromo-1-oxo-1,2-dihydroisoquinoline-4-carboxylic acid

: 108-00-9
N,N-dimethylethylenediamine

: 1070294-38-0
2-benzyl-6-bromo-N-(2-(dimethylamino)ethyl)-1-oxo-1,2-dihydroisoquinoline-4-carboxamide

Guidance literature:: 2-benzyl-6-bromo-1-oxo-1,2-dihydroisoquinoline-4-carboxylic acid; With N,N-dimethyl-formamide; oxalic acid diethyl ester; In dichloromethane; at 20 ℃; for 16h;

N,N-dimethylethylenediamine; With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 20 ℃; for 0.25h;

Reference yield:

: 1070293-84-3
2-benzyl-6-bromo-1-oxo-1,2-dihydroisoquinoline-4-carboxylic acid methyl ester

: 1070294-38-0
2-benzyl-6-bromo-N-(2-(dimethylamino)ethyl)-1-oxo-1,2-dihydroisoquinoline-4-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydroxide; water / methanol / 2 h / 70 °C

2.1: N,N-dimethyl-formamide; oxalic acid diethyl ester / dichloromethane / 16 h / 20 °C

2.2: 0.25 h / 0 - 20 °C

With sodium hydroxide; water; N,N-dimethyl-formamide; oxalic acid diethyl ester; In methanol; dichloromethane;

Reference yield:

: 943749-63-1
4-bromo-2-(carboxymethyl)benzoic acid

: 1070294-38-0
2-benzyl-6-bromo-N-(2-(dimethylamino)ethyl)-1-oxo-1,2-dihydroisoquinoline-4-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: acetic anhydride / 2 h / 120 °C

2.1: methanol; sulfuric acid / 19 h / Heating / reflux

3.1: methanol / 40 h / Heating / reflux

4.1: sodium hydroxide; water / methanol / 2 h / 70 °C

5.1: N,N-dimethyl-formamide; oxalic acid diethyl ester / dichloromethane / 16 h / 20 °C

5.2: 0.25 h / 0 - 20 °C

With methanol; sodium hydroxide; sulfuric acid; water; acetic anhydride; N,N-dimethyl-formamide; oxalic acid diethyl ester; In methanol; dichloromethane;