[1-ethoxycarbonylmethylsulfanyl-2-(4-methyl-benzoyl)-3-oxo-3-p-tolyl-propenylsulfanyl]-acetic acid ethyl ester

Base Information

• Chemical Name: [1-ethoxycarbonylmethylsulfanyl-2-(4-methyl-benzoyl)-3-oxo-3-p-tolyl-propenylsulfanyl]-acetic acid ethyl ester
• CAS No.: 281663-92-1
• Molecular Formula: C₂₆H₂₈O₆S₂
• Molecular Weight: 500.637

Synonyms:[1-ethoxycarbonylmethylsulfanyl-2-(4-methyl-benzoyl)-3-oxo-3-p-tolyl-propenylsulfanyl]-acetic acid ethyl ester

Chemical Property of [1-ethoxycarbonylmethylsulfanyl-2-(4-methyl-benzoyl)-3-oxo-3-p-tolyl-propenylsulfanyl]-acetic acid ethyl ester

Chemical Property:

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Technology Process of [1-ethoxycarbonylmethylsulfanyl-2-(4-methyl-benzoyl)-3-oxo-3-p-tolyl-propenylsulfanyl]-acetic acid ethyl ester

There total 1 articles about [1-ethoxycarbonylmethylsulfanyl-2-(4-methyl-benzoyl)-3-oxo-3-p-tolyl-propenylsulfanyl]-acetic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

carbon disulfide (75-15-0,12122-00-8) + 1,3-bis(p-methylphenyl)-1,3-propanedione (3594-36-3) + ethyl bromoacetate (105-36-2) → [1-ethoxycarbonylmethylsulfanyl-2-(4-methyl-benzoyl)-3-oxo-3-p-tolyl-propenylsulfanyl]-acetic acid ethyl ester (281663-92-1)

Guidance literature:

With potassium fluoride; In N,N-dimethyl-formamide; at 20 ℃; for 2h;

DOI:10.1080/00397910008087211

Reference yield: 70.0%

[1-ethoxycarbonylmethylsulfanyl-2-(4-methyl-benzoyl)-3-oxo-3-p-tolyl-propenylsulfanyl]-acetic acid ethyl ester (281663-92-1) → diethyl 3,4-bis(4-methylphenyl)thieno[2,3-b]thiophene-2,5-dicarboxylate (257953-67-6)

Guidance literature:

With sodium ethanolate; In ethanol; at 20 ℃; for 0.75h;

DOI:10.1080/00397910008087211

Reference yield:

[1-ethoxycarbonylmethylsulfanyl-2-(4-methyl-benzoyl)-3-oxo-3-p-tolyl-propenylsulfanyl]-acetic acid ethyl ester (281663-92-1) → 3,4-bis(4-methylphenyl)thieno[2,3-b]thiophene

Guidance literature:

Multi-step reaction with 3 steps

1: 70 percent / sodium ethoxide / ethanol / 0.75 h / 20 °C

2: 76 percent / aq. KOH / methanol / 48 h / Heating

3: 60 percent / 0.17 h / 250 - 260 °C

With potassium hydroxide; sodium ethanolate; In methanol; ethanol; 1: Dieckmann cyclization;

DOI:10.1080/00397910008087211

upstream raw materials:

carbon disulfide

1,3-bis(p-methylphenyl)-1,3-propanedione

ethyl bromoacetate

Downstream raw materials:

diethyl 3,4-bis(4-methylphenyl)thieno[2,3-b]thiophene-2,5-dicarboxylate

3,4-di-p-tolyl-thieno[2,3-b]thiophene-2,5-dicarboxylic acid

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