4-cyano-1-formyl-2,4,5,6-tetrahydro-4,6,6-tetramethylcyclopentapyrrole-3-carboxylic acid

Base Information

• Chemical Name: 4-cyano-1-formyl-2,4,5,6-tetrahydro-4,6,6-tetramethylcyclopentapyrrole-3-carboxylic acid
• CAS No.: 54609-75-5
• Molecular Formula: C₁₉H₁₈N₂O₃
• Molecular Weight: 322.364

Synonyms:4-cyano-1-formyl-2,4,5,6-tetrahydro-4,6,6-tetramethylcyclopentapyrrole-3-carboxylic acid

Chemical Property of 4-cyano-1-formyl-2,4,5,6-tetrahydro-4,6,6-tetramethylcyclopentapyrrole-3-carboxylic acid

Chemical Property:

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Technology Process of 4-cyano-1-formyl-2,4,5,6-tetrahydro-4,6,6-tetramethylcyclopentapyrrole-3-carboxylic acid

There total 3 articles about 4-cyano-1-formyl-2,4,5,6-tetrahydro-4,6,6-tetramethylcyclopentapyrrole-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

1-(dichloromethyl)-2-phenyl-2,4,5,6-tetrahydro-3-(trichloromethyl)-4,6,6-trimethylcyclopentapyrrole-4-carbonitrile (54609-74-4) → 4-cyano-1-formyl-2,4,5,6-tetrahydro-4,6,6-tetramethylcyclopentapyrrole-3-carboxylic acid (54609-75-5)

Guidance literature:

With potassium acetate; In acetic acid; for 2.5h; Heating;

DOI:10.1021/jm00182a024

Reference yield:

1,3,4,6,6-pentamethyl-2-phenyl-2,4,5,6-tetrahydro-cyclopenta[c]pyrrole-4-carbonitrile (54609-27-7) → 4-cyano-1-formyl-2,4,5,6-tetrahydro-4,6,6-tetramethylcyclopentapyrrole-3-carboxylic acid (54609-75-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 62 percent / SO₂Cl₂ / diethyl ether / Ambient temperature

2: 74 percent / potassium acetate / acetic acid / 2.5 h / Heating

With sulfuryl dichloride; potassium acetate; In diethyl ether; acetic acid;

DOI:10.1021/jm00182a024

Reference yield:

→ 4-cyano-1-formyl-2,4,5,6-tetrahydro-4,6,6-tetramethylcyclopentapyrrole-3-carboxylic acid (54609-75-5)

Guidance literature:

Entspr. 1-CHCl2-Verb., entspr. 3-CCl3-Verb.;

upstream raw materials:

1-(dichloromethyl)-2-phenyl-2,4,5,6-tetrahydro-3-(trichloromethyl)-4,6,6-trimethylcyclopentapyrrole-4-carbonitrile

1,3,4,6,6-pentamethyl-2-phenyl-2,4,5,6-tetrahydro-cyclopenta[c]pyrrole-4-carbonitrile

Downstream raw materials:

2-phenyl-2,4,5,6-tetrahydro-1,4,6,6-tetramethylcyclopentapyrrole-4-carboxylic acid

1-hydroxymethyl-4,6,6-trimethyl-2-phenyl-2,4,5,6-tetrahydro-cyclopenta[c]pyrrole-4-carboxylic acid amide

2-phenyl-2,4,5,6-tetrahydro-1,4,6,6-tetramethylcyclopentapyrrole-4-carboxamide

2-phenyl-1-formyl-2,4,5,6-tetrahydro-4,6,6-trimethylcyclopenta[c]-pyrrole-4-carboxamide

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