(1R,3aS,4R,7aR)-2-tert-butyl 1-methyl hexahydro-4-((3-tert-butyldiphenylsilyloxy)propyl)-3,6-dioxo-1H-isoindole-1,2(3H)-dicarboxylate

Base Information

Chemical Name:(1R,3aS,4R,7aR)-2-tert-butyl 1-methyl hexahydro-4-((3-tert-butyldiphenylsilyloxy)propyl)-3,6-dioxo-1H-isoindole-1,2(3H)-dicarboxylate
CAS No.:848476-35-7
Molecular Formula:C₃₄H₄₅NO₇Si
Molecular Weight:607.819
Hs Code.:

Synonyms:(1R,3aS,4R,7aR)-2-tert-butyl 1-methyl hexahydro-4-((3-tert-butyldiphenylsilyloxy)propyl)-3,6-dioxo-1H-isoindole-1,2(3H)-dicarboxylate

Suppliers and Price of (1R,3aS,4R,7aR)-2-tert-butyl 1-methyl hexahydro-4-((3-tert-butyldiphenylsilyloxy)propyl)-3,6-dioxo-1H-isoindole-1,2(3H)-dicarboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (1R,3aS,4R,7aR)-2-tert-butyl 1-methyl hexahydro-4-((3-tert-butyldiphenylsilyloxy)propyl)-3,6-dioxo-1H-isoindole-1,2(3H)-dicarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (1R,3aS,4R,7aR)-2-tert-butyl 1-methyl hexahydro-4-((3-tert-butyldiphenylsilyloxy)propyl)-3,6-dioxo-1H-isoindole-1,2(3H)-dicarboxylate

There total 7 articles about (1R,3aS,4R,7aR)-2-tert-butyl 1-methyl hexahydro-4-((3-tert-butyldiphenylsilyloxy)propyl)-3,6-dioxo-1H-isoindole-1,2(3H)-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 58479-61-1
tert-butylchlorodiphenylsilane

: 848476-43-7
(1R,3aS,4R,7aR)-2-tert-butyl 1-methyl hexahydro-4-(3-hydroxypropyl)-3,6-dioxo-1H-isoindole-1,2(3H)-dicarboxylate

: 848476-35-7
(1R,3aS,4R,7aR)-2-tert-butyl 1-methyl hexahydro-4-((3-tert-butyldiphenylsilyloxy)propyl)-3,6-dioxo-1H-isoindole-1,2(3H)-dicarboxylate

Guidance literature:: With 1H-imidazole; In dichloromethane; for 18h;
DOI:10.1021/ja042415g

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 848476-35-7
(1R,3aS,4R,7aR)-2-tert-butyl 1-methyl hexahydro-4-((3-tert-butyldiphenylsilyloxy)propyl)-3,6-dioxo-1H-isoindole-1,2(3H)-dicarboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: 90 percent / DMAP / CH₂Cl₂ / 18 h

2.1: sodium periodate; aq. ruthenium chloride / ethyl acetate; acetonitrile / 18 h / 20 °C

2.2: 64 percent / methanol; toluene; diethyl ether / 0.08 h

3.1: 71 percent / sodium methoxide / methanol / 1.5 h / -78 °C

4.1: 90 percent / imidazole / CH₂Cl₂ / 18 h

With 1H-imidazole; dmap; ruthenium trichloride; sodium periodate; sodium methylate; In methanol; dichloromethane; ethyl acetate; acetonitrile;
DOI:10.1021/ja042415g

Reference yield:

: 414871-53-7
(3S,3aS,7aR)-2-(1-methyl-1-phenylethyl)-3-phenyl-2,3,3a,7a-tetrahydro-1H-isoindole-1,5(4H)-dione

: 848476-35-7
(1R,3aS,4R,7aR)-2-tert-butyl 1-methyl hexahydro-4-((3-tert-butyldiphenylsilyloxy)propyl)-3,6-dioxo-1H-isoindole-1,2(3H)-dicarboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: tert-butyl lithium / diethyl ether; hexane / -78 - 20 °C

1.2: Li[Cu(CN)Me] / diethyl ether; hexane / 20 °C

1.3: 79 percent / diethyl ether; hexane / 2 h / -78 °C

2.1: 90 percent / 0.5 h / Heating

3.1: 90 percent / DMAP / CH₂Cl₂ / 18 h

4.1: sodium periodate; aq. ruthenium chloride / ethyl acetate; acetonitrile / 18 h / 20 °C

4.2: 64 percent / methanol; toluene; diethyl ether / 0.08 h

5.1: 71 percent / sodium methoxide / methanol / 1.5 h / -78 °C

6.1: 90 percent / imidazole / CH₂Cl₂ / 18 h

With 1H-imidazole; dmap; ruthenium trichloride; sodium periodate; tert.-butyl lithium; sodium methylate; In methanol; diethyl ether; hexane; dichloromethane; ethyl acetate; acetonitrile;
DOI:10.1021/ja042415g