(1R,3aR,4S,8aR)-2-tert-butyl 1-methyl hexahydro-4-((3-tert-butyldiphenylsilyloxy)propyl)-3,7-dioxo-1H-oxepino[4,5-c]pyrrole-1,2(7H)-dicarboxylate

Base Information

Chemical Name:(1R,3aR,4S,8aR)-2-tert-butyl 1-methyl hexahydro-4-((3-tert-butyldiphenylsilyloxy)propyl)-3,7-dioxo-1H-oxepino[4,5-c]pyrrole-1,2(7H)-dicarboxylate
CAS No.:848476-36-8
Molecular Formula:C₃₄H₄₅NO₈Si
Molecular Weight:623.819
Hs Code.:

Synonyms:(1R,3aR,4S,8aR)-2-tert-butyl 1-methyl hexahydro-4-((3-tert-butyldiphenylsilyloxy)propyl)-3,7-dioxo-1H-oxepino[4,5-c]pyrrole-1,2(7H)-dicarboxylate

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Chemical Property of (1R,3aR,4S,8aR)-2-tert-butyl 1-methyl hexahydro-4-((3-tert-butyldiphenylsilyloxy)propyl)-3,7-dioxo-1H-oxepino[4,5-c]pyrrole-1,2(7H)-dicarboxylate

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Technology Process of (1R,3aR,4S,8aR)-2-tert-butyl 1-methyl hexahydro-4-((3-tert-butyldiphenylsilyloxy)propyl)-3,7-dioxo-1H-oxepino[4,5-c]pyrrole-1,2(7H)-dicarboxylate

There total 7 articles about (1R,3aR,4S,8aR)-2-tert-butyl 1-methyl hexahydro-4-((3-tert-butyldiphenylsilyloxy)propyl)-3,7-dioxo-1H-oxepino[4,5-c]pyrrole-1,2(7H)-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 848476-35-7
(1R,3aS,4R,7aR)-2-tert-butyl 1-methyl hexahydro-4-((3-tert-butyldiphenylsilyloxy)propyl)-3,6-dioxo-1H-isoindole-1,2(3H)-dicarboxylate

: 848476-36-8
(1R,3aR,4S,8aR)-2-tert-butyl 1-methyl hexahydro-4-((3-tert-butyldiphenylsilyloxy)propyl)-3,7-dioxo-1H-oxepino[4,5-c]pyrrole-1,2(7H)-dicarboxylate

Guidance literature:: With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; for 72h;
DOI:10.1021/ja042415g

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 848476-36-8
(1R,3aR,4S,8aR)-2-tert-butyl 1-methyl hexahydro-4-((3-tert-butyldiphenylsilyloxy)propyl)-3,7-dioxo-1H-oxepino[4,5-c]pyrrole-1,2(7H)-dicarboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: 90 percent / DMAP / CH₂Cl₂ / 18 h

2.1: sodium periodate; aq. ruthenium chloride / ethyl acetate; acetonitrile / 18 h / 20 °C

2.2: 64 percent / methanol; toluene; diethyl ether / 0.08 h

3.1: 71 percent / sodium methoxide / methanol / 1.5 h / -78 °C

4.1: 90 percent / imidazole / CH₂Cl₂ / 18 h

5.1: 100 percent / mCPBA / CH₂Cl₂ / 72 h

With 1H-imidazole; dmap; ruthenium trichloride; sodium periodate; sodium methylate; 3-chloro-benzenecarboperoxoic acid; In methanol; dichloromethane; ethyl acetate; acetonitrile; 5.1: Baeyer-Villiger oxidation;
DOI:10.1021/ja042415g

Reference yield:

: 848476-42-6
3-((3R,3aR,7R,7aS)-octahydro-1,5-dioxo-3-phenyl-1H-isoindol-7-yl)propyl formate

: 848476-36-8
(1R,3aR,4S,8aR)-2-tert-butyl 1-methyl hexahydro-4-((3-tert-butyldiphenylsilyloxy)propyl)-3,7-dioxo-1H-oxepino[4,5-c]pyrrole-1,2(7H)-dicarboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: 90 percent / DMAP / CH₂Cl₂ / 18 h

2.1: sodium periodate; aq. ruthenium chloride / ethyl acetate; acetonitrile / 18 h / 20 °C

2.2: 64 percent / methanol; toluene; diethyl ether / 0.08 h

3.1: 71 percent / sodium methoxide / methanol / 1.5 h / -78 °C

4.1: 90 percent / imidazole / CH₂Cl₂ / 18 h

5.1: 100 percent / mCPBA / CH₂Cl₂ / 72 h

With 1H-imidazole; dmap; ruthenium trichloride; sodium periodate; sodium methylate; 3-chloro-benzenecarboperoxoic acid; In methanol; dichloromethane; ethyl acetate; acetonitrile; 5.1: Baeyer-Villiger oxidation;
DOI:10.1021/ja042415g