2-(4-(4-(1,1,1,3,3,3-hexafluoro-2-(methoxymethoxy)propan-2-yl)-2-propylphenoxy)-2-methylphenyl)ethan-1-ol

Base Information

Chemical Name:2-(4-(4-(1,1,1,3,3,3-hexafluoro-2-(methoxymethoxy)propan-2-yl)-2-propylphenoxy)-2-methylphenyl)ethan-1-ol
CAS No.:1198166-36-7
Molecular Formula:C₂₃H₂₆F₆O₄
Molecular Weight:480.447
Hs Code.:

Synonyms:2-(4-(4-(1,1,1,3,3,3-hexafluoro-2-(methoxymethoxy)propan-2-yl)-2-propylphenoxy)-2-methylphenyl)ethan-1-ol

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Chemical Property of 2-(4-(4-(1,1,1,3,3,3-hexafluoro-2-(methoxymethoxy)propan-2-yl)-2-propylphenoxy)-2-methylphenyl)ethan-1-ol

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Technology Process of 2-(4-(4-(1,1,1,3,3,3-hexafluoro-2-(methoxymethoxy)propan-2-yl)-2-propylphenoxy)-2-methylphenyl)ethan-1-ol

There total 6 articles about 2-(4-(4-(1,1,1,3,3,3-hexafluoro-2-(methoxymethoxy)propan-2-yl)-2-propylphenoxy)-2-methylphenyl)ethan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-(1,1,1,3,3,3-hexafluoro-2-(methoxymethoxy)propan-2-yl)-1-(3-methyl-4-vinylphenoxy)-2-propylbenzene: 1198166-35-6
4-(1,1,1,3,3,3-hexafluoro-2-(methoxymethoxy)propan-2-yl)-1-(3-methyl-4-vinylphenoxy)-2-propylbenzene

: 1198166-36-7
2-(4-(4-(1,1,1,3,3,3-hexafluoro-2-(methoxymethoxy)propan-2-yl)-2-propylphenoxy)-2-methylphenyl)ethan-1-ol

Guidance literature:: 4-(1,1,1,3,3,3-hexafluoro-2-(methoxymethoxy)propan-2-yl)-1-(3-methyl-4-vinylphenoxy)-2-propylbenzene; With borane-THF; In tetrahydrofuran; at 0 ℃; for 1h; Inert atmosphere;

With sodium peroxoborate tetrahydrate; In tetrahydrofuran; at 0 - 20 ℃; Inert atmosphere;
DOI:10.1016/j.bmc.2016.05.048

Reference yield:

: 1198166-32-3
2-methyl-4-[2-n-propyl-4-(2,2,2-trifluoro-1-methoxymethoxy-1-trifluoromethylethyl)phenoxy]-1-nitrobenzene

: 1198166-36-7
2-(4-(4-(1,1,1,3,3,3-hexafluoro-2-(methoxymethoxy)propan-2-yl)-2-propylphenoxy)-2-methylphenyl)ethan-1-ol

Guidance literature:: Multi-step reaction with 4 steps

1.1: palladium on activated charcoal; hydrogen / methanol / 3 h / 20 °C

2.1: potassium iodide; toluene-4-sulfonic acid; sodium nitrite / water; acetonitrile / 0 - 10 °C

3.1: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide; water / 80 °C / Microwave irradiation

4.1: borane-THF / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere

4.2: 0 - 20 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; borane-THF; palladium on activated charcoal; hydrogen; sodium carbonate; toluene-4-sulfonic acid; potassium iodide; sodium nitrite; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; acetonitrile; 3.1: |Suzuki-Miyaura Coupling;
DOI:10.1016/j.bmc.2016.05.048

Reference yield:

4-(1,1,1,3,3,3-hexafluoro-2-(methoxymethoxy)propan-2-yl)-1-(4-iodo-3-methylphenoxy)-2-n-propylbenzene: 1198166-34-5
4-(1,1,1,3,3,3-hexafluoro-2-(methoxymethoxy)propan-2-yl)-1-(4-iodo-3-methylphenoxy)-2-n-propylbenzene

: 1198166-36-7
2-(4-(4-(1,1,1,3,3,3-hexafluoro-2-(methoxymethoxy)propan-2-yl)-2-propylphenoxy)-2-methylphenyl)ethan-1-ol

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide; water / 80 °C / Microwave irradiation

2.1: borane-THF / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere

2.2: 0 - 20 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; borane-THF; sodium carbonate; In tetrahydrofuran; water; N,N-dimethyl-formamide; 1.1: |Suzuki-Miyaura Coupling;
DOI:10.1016/j.bmc.2016.05.048