methyl 3-{[1-(3-chloro-4-cyanophenyl)-3,5-dimethyl-1H-pyrazol-4-yl]methyl}benzoate

Base Information

Chemical Name:methyl 3-{[1-(3-chloro-4-cyanophenyl)-3,5-dimethyl-1H-pyrazol-4-yl]methyl}benzoate
CAS No.:1189135-70-3
Molecular Formula:C₂₁H₁₈ClN₃O₂
Molecular Weight:379.846
Hs Code.:

Synonyms:methyl 3-{[1-(3-chloro-4-cyanophenyl)-3,5-dimethyl-1H-pyrazol-4-yl]methyl}benzoate

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Chemical Property of methyl 3-{[1-(3-chloro-4-cyanophenyl)-3,5-dimethyl-1H-pyrazol-4-yl]methyl}benzoate

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Technology Process of methyl 3-{[1-(3-chloro-4-cyanophenyl)-3,5-dimethyl-1H-pyrazol-4-yl]methyl}benzoate

There total 5 articles about methyl 3-{[1-(3-chloro-4-cyanophenyl)-3,5-dimethyl-1H-pyrazol-4-yl]methyl}benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 1189140-64-4
methyl 3-[(3,5-dimethyl-1H-pyrazol-4-yl)methyl]-benzoate

: 60702-69-4
2-chloro-4-fluorobenzonitrile

: 1189135-70-3
methyl 3-{[1-(3-chloro-4-cyanophenyl)-3,5-dimethyl-1H-pyrazol-4-yl]methyl}benzoate

Guidance literature:: methyl 3-[(3,5-dimethyl-1H-pyrazol-4-yl)methyl]-benzoate; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 ℃; for 0.5h;

2-chloro-4-fluorobenzonitrile; In N,N-dimethyl-formamide; mineral oil; at 0 - 20 ℃; for 20h;
DOI:10.1016/j.bmc.2012.02.005

Reference yield:

: 791809-55-7
3-(2-acetyl-3-oxo-butyl)-benzoic acid methyl ester

: 1189135-70-3
methyl 3-{[1-(3-chloro-4-cyanophenyl)-3,5-dimethyl-1H-pyrazol-4-yl]methyl}benzoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrazine hydrate / ethanol / 2 h / Reflux

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C

2.2: 20 h / 0 - 20 °C

With sodium hydride; hydrazine hydrate; In ethanol; N,N-dimethyl-formamide; mineral oil;
DOI:10.1016/j.bmc.2012.02.005

Reference yield:

: 34040-63-6
methyl 3-(chloromethyl)benzoate

: 1189135-70-3
methyl 3-{[1-(3-chloro-4-cyanophenyl)-3,5-dimethyl-1H-pyrazol-4-yl]methyl}benzoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium ethanolate / ethanol / 2.5 h / 50 °C / Reflux

2.1: hydrazine hydrate / ethanol / 2 h / Reflux

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C

3.2: 20 h / 0 - 20 °C

With sodium ethanolate; sodium hydride; hydrazine hydrate; In ethanol; N,N-dimethyl-formamide; mineral oil;
DOI:10.1016/j.bmc.2012.02.005