(4R,5S,2'R)-(+)-4-methyl-5-phenyl-3-[2-hydroxy-4-triethylsilyloxy-4-methylpentanoyl]-2-oxazolidinone

Base Information

Chemical Name:(4R,5S,2'R)-(+)-4-methyl-5-phenyl-3-[2-hydroxy-4-triethylsilyloxy-4-methylpentanoyl]-2-oxazolidinone
CAS No.:383397-36-2
Molecular Formula:C₂₂H₃₅NO₅Si
Molecular Weight:421.609
Hs Code.:

Synonyms:(4R,5S,2'R)-(+)-4-methyl-5-phenyl-3-[2-hydroxy-4-triethylsilyloxy-4-methylpentanoyl]-2-oxazolidinone

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Chemical Property of (4R,5S,2'R)-(+)-4-methyl-5-phenyl-3-[2-hydroxy-4-triethylsilyloxy-4-methylpentanoyl]-2-oxazolidinone

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Technology Process of (4R,5S,2'R)-(+)-4-methyl-5-phenyl-3-[2-hydroxy-4-triethylsilyloxy-4-methylpentanoyl]-2-oxazolidinone

There total 8 articles about (4R,5S,2'R)-(+)-4-methyl-5-phenyl-3-[2-hydroxy-4-triethylsilyloxy-4-methylpentanoyl]-2-oxazolidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 383397-33-9
(4R,5S)-(+)-4-methyl-5-phenyl-3-[4-triethylsilyloxy-4-methylpentanoyl]-2-oxazolidinone

: 383397-36-2
(4R,5S,2'R)-(+)-4-methyl-5-phenyl-3-[2-hydroxy-4-triethylsilyloxy-4-methylpentanoyl]-2-oxazolidinone

Guidance literature:: (4R,5S)-(+)-4-methyl-5-phenyl-3-[4-triethylsilyloxy-4-methylpentanoyl]-2-oxazolidinone; With sodium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 0.5h;

With N-(benzenesulfonyl)-3-phenyloxaziridine; In tetrahydrofuran; at -78 ℃; for 0.166667h; Further stages.;
DOI:10.1021/jo015953+

Reference yield:

: 3123-97-5
dihydro-5,5-dimethyl-2(3H)-furanone

: 383397-36-2
(4R,5S,2'R)-(+)-4-methyl-5-phenyl-3-[2-hydroxy-4-triethylsilyloxy-4-methylpentanoyl]-2-oxazolidinone

Guidance literature:: Multi-step reaction with 3 steps

1.1: 93 percent / Me₃COCl; Et₃N; DMAP

2.1: NaN(TMS)2

2.2: 84 percent / 2-phenylsulfonyl-3-phenyl-1-oxa-2-azacyclopropane

With dmap; sodium hexamethyldisilazane; pivaloyl chloride; triethylamine;
DOI:10.1021/ol991042z

Reference yield:

: 383397-31-7
4-triethylsilyloxy-4-methylpentanoic acid

: 383397-36-2
(4R,5S,2'R)-(+)-4-methyl-5-phenyl-3-[2-hydroxy-4-triethylsilyloxy-4-methylpentanoyl]-2-oxazolidinone

Guidance literature:: Multi-step reaction with 2 steps

1.1: 93 percent / Me₃COCl; Et₃N; DMAP

2.1: NaN(TMS)2

2.2: 84 percent / 2-phenylsulfonyl-3-phenyl-1-oxa-2-azacyclopropane

With dmap; sodium hexamethyldisilazane; pivaloyl chloride; triethylamine;
DOI:10.1021/ol991042z