N, N-bis(tert-butoxycarbonyl)-3-(1-(2,5-dichlorophenyl)ethoxy)-5-(6-trityl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-3-yl)pyridin-2-amine

Base Information

Chemical Name:N, N-bis(tert-butoxycarbonyl)-3-(1-(2,5-dichlorophenyl)ethoxy)-5-(6-trityl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-3-yl)pyridin-2-amine
CAS No.:1613148-38-1
Molecular Formula:C₄₉H₄₈Cl₂N₄O₅
Molecular Weight:843.85
Hs Code.:

Synonyms:N, N-bis(tert-butoxycarbonyl)-3-(1-(2,5-dichlorophenyl)ethoxy)-5-(6-trityl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-3-yl)pyridin-2-amine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N, N-bis(tert-butoxycarbonyl)-3-(1-(2,5-dichlorophenyl)ethoxy)-5-(6-trityl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-3-yl)pyridin-2-amine

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of N, N-bis(tert-butoxycarbonyl)-3-(1-(2,5-dichlorophenyl)ethoxy)-5-(6-trityl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-3-yl)pyridin-2-amine

There total 11 articles about N, N-bis(tert-butoxycarbonyl)-3-(1-(2,5-dichlorophenyl)ethoxy)-5-(6-trityl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-3-yl)pyridin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 905273-35-0
3-bromo-6-trityl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridine

: 1613148-35-8
N,N-bis(tert-butoxycarbonyl)-3-(1-(2,5-dichlorophenyl)ethoxy)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-amine

: 1613148-38-1
N, N-bis(tert-butoxycarbonyl)-3-(1-(2,5-dichlorophenyl)ethoxy)-5-(6-trityl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-3-yl)pyridin-2-amine

Guidance literature:: With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; caesium carbonate; In 1,2-dimethoxyethane; water; at 90 ℃; for 12.25h; Inert atmosphere;

Reference yield:

: 54231-35-5
3-fuoro-2-nitropyridine

: 1613148-38-1
N, N-bis(tert-butoxycarbonyl)-3-(1-(2,5-dichlorophenyl)ethoxy)-5-(6-trityl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-3-yl)pyridin-2-amine

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0 °C

1.2: 20 °C

2.1: iron; acetic acid / 1 h / 100 °C

3.1: N-Bromosuccinimide / acetonitrile / 2 h / 0 °C

4.1: triethylamine; dmap / tetrahydrofuran / 75 °C

5.1: potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / dimethyl sulfoxide / 90 °C / Inert atmosphere

6.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; caesium carbonate / 1,2-dimethoxyethane; water / 12.25 h / 90 °C / Inert atmosphere

With dmap; N-Bromosuccinimide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; iron; sodium hydride; caesium carbonate; acetic acid; triethylamine; In tetrahydrofuran; 1,2-dimethoxyethane; water; dimethyl sulfoxide; acetonitrile; mineral oil;

Reference yield:

: 1356330-71-6
5-bromo-2,3-bis(hydroxymethyl)pyridine

: 1613148-38-1
N, N-bis(tert-butoxycarbonyl)-3-(1-(2,5-dichlorophenyl)ethoxy)-5-(6-trityl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-3-yl)pyridin-2-amine

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogen bromide / 24 h / 130 °C

1.2: 24 h / 130 °C

2.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2 h / 60 °C

3.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; caesium carbonate / 1,2-dimethoxyethane; water / 12.25 h / 90 °C / Inert atmosphere

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; hydrogen bromide; caesium carbonate; N-ethyl-N,N-diisopropylamine; In 1,2-dimethoxyethane; water; N,N-dimethyl-formamide;