(R)-3-(2-amino-2-phenylethyl)-1-(2-fluoro-6-(trifluoromethyl)benzyl)-1'-(3-fluorobenzyl)-1H-spiro[furo[3,4-d]pyrimidine-5,4'-piperidine]-2,4(3H,7H)-dione

Base Information

• Chemical Name: (R)-3-(2-amino-2-phenylethyl)-1-(2-fluoro-6-(trifluoromethyl)benzyl)-1'-(3-fluorobenzyl)-1H-spiro[furo[3,4-d]pyrimidine-5,4'-piperidine]-2,4(3H,7H)-dione
• CAS No.: 1454272-04-8
• Molecular Formula: C₃₃H₃₁F₅N₄O₃
• Molecular Weight: 626.626

Synonyms:(R)-3-(2-amino-2-phenylethyl)-1-(2-fluoro-6-(trifluoromethyl)benzyl)-1'-(3-fluorobenzyl)-1H-spiro[furo[3,4-d]pyrimidine-5,4'-piperidine]-2,4(3H,7H)-dione

Chemical Property of (R)-3-(2-amino-2-phenylethyl)-1-(2-fluoro-6-(trifluoromethyl)benzyl)-1'-(3-fluorobenzyl)-1H-spiro[furo[3,4-d]pyrimidine-5,4'-piperidine]-2,4(3H,7H)-dione

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Technology Process of (R)-3-(2-amino-2-phenylethyl)-1-(2-fluoro-6-(trifluoromethyl)benzyl)-1'-(3-fluorobenzyl)-1H-spiro[furo[3,4-d]pyrimidine-5,4'-piperidine]-2,4(3H,7H)-dione

There total 15 articles about (R)-3-(2-amino-2-phenylethyl)-1-(2-fluoro-6-(trifluoromethyl)benzyl)-1'-(3-fluorobenzyl)-1H-spiro[furo[3,4-d]pyrimidine-5,4'-piperidine]-2,4(3H,7H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

→ (R)-3-(2-amino-2-phenylethyl)-1-(2-fluoro-6-(trifluoromethyl)benzyl)-1'-(3-fluorobenzyl)-1H-spiro[furo[3,4-d]pyrimidine-5,4'-piperidine]-2,4(3H,7H)-dione (1454272-04-8)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2.5h;

Reference yield: 79.0%

(R)-tert-butyl (2-(1-(2-fluoro-6-(trifluoromethyl)benzyl)-1'-(3-fluorobenzyl)-2,4-dioxo-1H-spiro[furo[3,4-d]pyrimidine-5 ,4'-piperidin]-3(2H,4H,7H)-yl)-1-phenylethyl)carbamate (1454273-46-1) → (R)-3-(2-amino-2-phenylethyl)-1-(2-fluoro-6-(trifluoromethyl)benzyl)-1'-(3-fluorobenzyl)-1H-spiro[furo[3,4-d]pyrimidine-5,4'-piperidine]-2,4(3H,7H)-dione (1454272-04-8)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2.5h;

Reference yield: 79.0%

(R)-tert-butyl (2-(1-(2-fluoro-6-(trifluoromethyl)benzyl)-1'-(3-fluorobenzyl)-2,4-dioxo-1H-spiro[furo[3,4-d]pyrimidine-5,4'-piperidin]-3(2H,4H,7H)-yl)-1-phenylethyl)carbamate → (R)-3-(2-amino-2-phenylethyl)-1-(2-fluoro-6-(trifluoromethyl)benzyl)-1'-(3-fluorobenzyl)-1H-spiro[furo[3,4-d]pyrimidine-5,4'-piperidine]-2,4(3H,7H)-dione (1454272-04-8)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2.5h;

upstream raw materials:

ethyl 8-benzyl-3-ureido-1-oxa-8-azaspiro[4.5]dec-3-en-4-carboxylate

1'-benzyl-1H-spiro[furo[3,4-d]pyrimidin-5,4'-piperidine]-2.4(3H,7H)-dione

1'-benzyl-1-(2-fluoro-6-(trifluoromethyl)benzyl)-1H-spiro[furo[3,4-d]pyrimidine-5,4'-piperidine]-2_,4(3H,7H)-dione

(R)-tert-butyl (2-(1'-benzyl-1-(2-fluoro-6-(trifluoromethyl)benzyl)-2,4-dioxo-1H-spiro[furo[3,4-d]pyrimidine-5,4'-piperidin]-3(2H,4H,7H)-yl)-1-phenylethyl)carbamate

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