(R)-tert-butyl (2-(1-(2-fluoro-6-(trifluoromethyl)benzyl)-1'-(3-fluorobenzyl)-2,4-dioxo-1H-spiro[furo[3,4-d]pyrimidine-5 ,4'-piperidin]-3(2H,4H,7H)-yl)-1-phenylethyl)carbamate

Base Information

Chemical Name:(R)-tert-butyl (2-(1-(2-fluoro-6-(trifluoromethyl)benzyl)-1'-(3-fluorobenzyl)-2,4-dioxo-1H-spiro[furo[3,4-d]pyrimidine-5 ,4'-piperidin]-3(2H,4H,7H)-yl)-1-phenylethyl)carbamate
CAS No.:1454273-46-1
Molecular Formula:C₃₈H₃₉F₅N₄O₅
Molecular Weight:726.743
Hs Code.:

(R)-tert-butyl (2-(1-(2-fluoro-6-(trifluoromethyl)benzyl)-1'-(3-fluorobenzyl)-2,4-dioxo-1H-spiro[furo[3,4-d]pyrimidine-5 ,4'-piperidin]-3(2H,4H,7H)-yl)-1-phenylethyl)carbamate

Synonyms:(R)-tert-butyl (2-(1-(2-fluoro-6-(trifluoromethyl)benzyl)-1'-(3-fluorobenzyl)-2,4-dioxo-1H-spiro[furo[3,4-d]pyrimidine-5 ,4'-piperidin]-3(2H,4H,7H)-yl)-1-phenylethyl)carbamate

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Chemical Property of (R)-tert-butyl (2-(1-(2-fluoro-6-(trifluoromethyl)benzyl)-1'-(3-fluorobenzyl)-2,4-dioxo-1H-spiro[furo[3,4-d]pyrimidine-5 ,4'-piperidin]-3(2H,4H,7H)-yl)-1-phenylethyl)carbamate

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Technology Process of (R)-tert-butyl (2-(1-(2-fluoro-6-(trifluoromethyl)benzyl)-1'-(3-fluorobenzyl)-2,4-dioxo-1H-spiro[furo[3,4-d]pyrimidine-5 ,4'-piperidin]-3(2H,4H,7H)-yl)-1-phenylethyl)carbamate

There total 10 articles about (R)-tert-butyl (2-(1-(2-fluoro-6-(trifluoromethyl)benzyl)-1'-(3-fluorobenzyl)-2,4-dioxo-1H-spiro[furo[3,4-d]pyrimidine-5 ,4'-piperidin]-3(2H,4H,7H)-yl)-1-phenylethyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 1454273-45-0
(R)-tert-butyl (2-(1-(2-fluoro-6-(trifluoromethyl)benzyl)-2,4-dioxo-1H-spiro[furo[3,4-d]pyrimidine-5,4'-piperidin]-3(2H,4H,7H)-yl)-1-phenylethyl)carbamate

: 456-41-7
1-(Bromomethyl)-3-fluorobenzene

: 1454273-46-1
(R)-tert-butyl (2-(1-(2-fluoro-6-(trifluoromethyl)benzyl)-1'-(3-fluorobenzyl)-2,4-dioxo-1H-spiro[furo[3,4-d]pyrimidine-5 ,4'-piperidin]-3(2H,4H,7H)-yl)-1-phenylethyl)carbamate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 15h;

Reference yield:

: 3612-20-2
1-phenylmethyl-4-piperidone

: 1454273-46-1
(R)-tert-butyl (2-(1-(2-fluoro-6-(trifluoromethyl)benzyl)-1'-(3-fluorobenzyl)-2,4-dioxo-1H-spiro[furo[3,4-d]pyrimidine-5 ,4'-piperidin]-3(2H,4H,7H)-yl)-1-phenylethyl)carbamate

Guidance literature:: Multi-step reaction with 8 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 20 °C / Cooling with ice

1.2: 0.5 h / 20 °C / Cooling with ice; Inert atmosphere

2.1: sodium hydride / mineral oil; 1,4-dioxane / 20 °C / Cooling with ice

2.2: 15 h / 20 - 80 °C

3.1: acetic acid / toluene / 12 h / 70 °C

4.1: dichloromethane / 4 h / 0 - 20 °C / Inert atmosphere

5.1: sodium hydroxide / ethanol; water / 12 h / 70 °C

6.1: potassium carbonate; tetrabutylammomium bromide / acetone / 15 h / 70 °C

7.1: hydrogen; palladium on carbon / methanol / 15 h

8.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 15 h / 20 °C

With palladium on carbon; tetrabutylammomium bromide; hydrogen; sodium hydride; potassium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; water; acetone; toluene; mineral oil;

Reference yield:

: 40110-55-2
ethyl 2-(1-benzylpiperidine-4-ylidene)acetate

: 1454273-46-1
(R)-tert-butyl (2-(1-(2-fluoro-6-(trifluoromethyl)benzyl)-1'-(3-fluorobenzyl)-2,4-dioxo-1H-spiro[furo[3,4-d]pyrimidine-5 ,4'-piperidin]-3(2H,4H,7H)-yl)-1-phenylethyl)carbamate

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium hydride / mineral oil; 1,4-dioxane / 20 °C / Cooling with ice

1.2: 15 h / 20 - 80 °C

2.1: acetic acid / toluene / 12 h / 70 °C

3.1: dichloromethane / 4 h / 0 - 20 °C / Inert atmosphere

4.1: sodium hydroxide / ethanol; water / 12 h / 70 °C

5.1: potassium carbonate; tetrabutylammomium bromide / acetone / 15 h / 70 °C

6.1: hydrogen; palladium on carbon / methanol / 15 h

7.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 15 h / 20 °C

With palladium on carbon; tetrabutylammomium bromide; hydrogen; sodium hydride; potassium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In 1,4-dioxane; methanol; ethanol; dichloromethane; water; acetone; toluene; mineral oil;