[3-(tert-Butyl-diphenyl-silanyloxy)-1-methoxy-propyl]-carbamic acid tert-butyl ester

Base Information

• Chemical Name: [3-(tert-Butyl-diphenyl-silanyloxy)-1-methoxy-propyl]-carbamic acid tert-butyl ester
• CAS No.: 122716-72-7
• Molecular Formula: C₂₅H₃₇NO₄Si
• Molecular Weight: 443.659
• Mol file: 122716-72-7.mol

Synonyms:[3-(tert-Butyl-diphenyl-silanyloxy)-1-methoxy-propyl]-carbamic acid tert-butyl ester

Chemical Property of [3-(tert-Butyl-diphenyl-silanyloxy)-1-methoxy-propyl]-carbamic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [3-(tert-Butyl-diphenyl-silanyloxy)-1-methoxy-propyl]-carbamic acid tert-butyl ester

There total 2 articles about [3-(tert-Butyl-diphenyl-silanyloxy)-1-methoxy-propyl]-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

(3-Hydroxy-1-methoxy-propyl)-carbamic acid tert-butyl ester (122716-73-8) + tert-butylchlorodiphenylsilane (58479-61-1) → [3-(tert-Butyl-diphenyl-silanyloxy)-1-methoxy-propyl]-carbamic acid tert-butyl ester (122716-72-7)

Guidance literature:

With 1H-imidazole; In N,N-dimethyl-formamide; at 0 ℃; for 2h;

DOI:10.1016/S0040-4039(00)72728-6

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → [3-(tert-Butyl-diphenyl-silanyloxy)-1-methoxy-propyl]-carbamic acid tert-butyl ester (122716-72-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 2.) Et₄NOTs / 1.) CHCl₃, reflux, 3 h. 2.) electrolysis

2: 80 percent / imidazole / dimethylformamide / 2 h / 0 °C

With 1H-imidazole; tetraethylammonium tosylate; In N,N-dimethyl-formamide;

DOI:10.1016/S0040-4039(00)72728-6

Reference yield: 86.0%

3-(1-oxobutyl)-4-(S)-(1-methylethyl)-2-oxazolidinone (80697-93-4) + [3-(tert-Butyl-diphenyl-silanyloxy)-1-methoxy-propyl]-carbamic acid tert-butyl ester (122716-72-7) → C34H50N2O6Si

Guidance literature:

3-(1-oxobutyl)-4-(S)-(1-methylethyl)-2-oxazolidinone; [3-(tert-Butyl-diphenyl-silanyloxy)-1-methoxy-propyl]-carbamic acid tert-butyl ester; With lithium diisopropyl amide; In tetrahydrofuran; hexane; at -70 ℃; for 0.25h;

titanium tetrachloride; at -70 ℃; for 3h; Further stages.;

DOI:10.1021/ol991053s

upstream raw materials:

(3-Hydroxy-1-methoxy-propyl)-carbamic acid tert-butyl ester

tert-butylchlorodiphenylsilane

di-tert-butyl dicarbonate

Downstream raw materials:

(2S,3S)-3-tert-Butoxycarbonylamino-5-(tert-butyl-diphenyl-silanyloxy)-2-ethyl-pentanoic acid methyl ester

(2R,3S)-3-tert-Butoxycarbonylamino-5-(tert-butyl-diphenyl-silanyloxy)-2-ethyl-pentanoic acid methyl ester

(2S,3S)-3-tert-Butoxycarbonylamino-5-(tert-butyl-diphenyl-silanyloxy)-2-ethyl-pentanoic acid isopropyl ester

(2R,3S)-3-tert-Butoxycarbonylamino-5-(tert-butyl-diphenyl-silanyloxy)-2-ethyl-pentanoic acid isopropyl ester