4-((N-(4-(trifluoromethyl)benzyl)carbamoyl)methyl)-piperidine hydrochloride

Base Information

• Chemical Name: 4-((N-(4-(trifluoromethyl)benzyl)carbamoyl)methyl)-piperidine hydrochloride
• CAS No.: 301232-40-6
• Molecular Formula: C₁₅H₁₉F₃N₂O*ClH
• Molecular Weight: 336.785

Synonyms:4-((N-(4-(trifluoromethyl)benzyl)carbamoyl)methyl)-piperidine hydrochloride

Chemical Property of 4-((N-(4-(trifluoromethyl)benzyl)carbamoyl)methyl)-piperidine hydrochloride

Chemical Property:

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Technology Process of 4-((N-(4-(trifluoromethyl)benzyl)carbamoyl)methyl)-piperidine hydrochloride

There total 1 articles about 4-((N-(4-(trifluoromethyl)benzyl)carbamoyl)methyl)-piperidine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(3-(N,N-dimethylamino)-prop-1-yl)-3-ethylcarbodiimide hydrochloride (EDC) + p-Trifluoromethylbenzylamine (3300-51-4) + 2-(1-(tert-butoxycarbonyl)piperidin-4-yl)acetic acid (157688-46-5) → 4-((N-(4-(trifluoromethyl)benzyl)carbamoyl)methyl)-piperidine hydrochloride (301232-40-6)

Guidance literature:

With dmap; In hydrogenchloride; methanol; dichloromethane;

Reference yield:

2-(R)-(3-(R)-formyl-4-(S)-(3-fluorophenyl)-pyrrolidin-1-yl)-2-(cyclohexyl)acetic acid, 4-(methoxy)benzyl ester + 4-((N-(4-(trifluoromethyl)benzyl)carbamoyl)methyl)-piperidine hydrochloride (301232-40-6) → 2-(R)-(3-(S)-(4-((N-(4-(trifluoromethyl)benzyl)carbamoyl)methyl)piperidin-1-yl)methyl-4-(S)-(3-fluorophenyl)-pyrrolidin-1-yl)-2-(cyclohexyl)acetic acid

Guidance literature:

upstream raw materials:

p-Trifluoromethylbenzylamine

2-(1-(tert-butoxycarbonyl)piperidin-4-yl)acetic acid

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