Benzyl 4-((7-bromo-2-(2,4-dimethoxybenzyl)-1-oxo-1,2-dihydropyrrolo[1,2-a]pyrazin-4-yl)methyl)benzylcarbamate

Base Information

Chemical Name:Benzyl 4-((7-bromo-2-(2,4-dimethoxybenzyl)-1-oxo-1,2-dihydropyrrolo[1,2-a]pyrazin-4-yl)methyl)benzylcarbamate
CAS No.:1338811-42-9
Molecular Formula:C₃₂H₃₀BrN₃O₅
Molecular Weight:616.511
Hs Code.:

Synonyms:Benzyl 4-((7-bromo-2-(2,4-dimethoxybenzyl)-1-oxo-1,2-dihydropyrrolo[1,2-a]pyrazin-4-yl)methyl)benzylcarbamate

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Chemical Property of Benzyl 4-((7-bromo-2-(2,4-dimethoxybenzyl)-1-oxo-1,2-dihydropyrrolo[1,2-a]pyrazin-4-yl)methyl)benzylcarbamate

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Technology Process of Benzyl 4-((7-bromo-2-(2,4-dimethoxybenzyl)-1-oxo-1,2-dihydropyrrolo[1,2-a]pyrazin-4-yl)methyl)benzylcarbamate

There total 1 articles about Benzyl 4-((7-bromo-2-(2,4-dimethoxybenzyl)-1-oxo-1,2-dihydropyrrolo[1,2-a]pyrazin-4-yl)methyl)benzylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1338811-41-8
benzyl 4-(3-(4-bromo-N-(2,4-dimethoxybenzyl)-1H-pyrrole-2-carboxamido)prop-1-ynyl)benzylcarbamate

: 1338811-42-9
Benzyl 4-((7-bromo-2-(2,4-dimethoxybenzyl)-1-oxo-1,2-dihydropyrrolo[1,2-a]pyrazin-4-yl)methyl)benzylcarbamate

Guidance literature:: With tetrabutyl-ammonium chloride; sodium acetate; palladium diacetate; In N,N-dimethyl-formamide; at 120 ℃; for 0.5h;

Reference yield:

: 886547-94-0
1-(phenylsulfonyl)-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrolo[2,3-b]pyridine

: 1338811-42-9
Benzyl 4-((7-bromo-2-(2,4-dimethoxybenzyl)-1-oxo-1,2-dihydropyrrolo[1,2-a]pyrazin-4-yl)methyl)benzylcarbamate

: 1338811-43-0
Benzyl-4-((2-(2,4-dimethoxybenzyl)-1-oxo-7-(1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-1,2-dihydropyrrolo[1,2-a]pyrazin-4-yl)methyl)benzylcarbamate

Guidance literature:: With caesium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; water; at 85 ℃; Inert atmosphere;

Reference yield:

: 1338811-42-9
Benzyl 4-((7-bromo-2-(2,4-dimethoxybenzyl)-1-oxo-1,2-dihydropyrrolo[1,2-a]pyrazin-4-yl)methyl)benzylcarbamate

: 1338811-07-6
4-[4-(aminomethyl)benzyl]-7-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyrrolo[1,2-a]pyrazin-1(2H)-one

Guidance literature:: Multi-step reaction with 3 steps

1: caesium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 85 °C / Inert atmosphere

2: sodium hydroxide / 1,4-dioxane / 5 h / 50 °C

3: trifluoroacetic acid; chlorotriisopropylsilane / dichloromethane / 0.67 h / 120 °C / Microwave irradiation

With chlorotriisopropylsilane; caesium carbonate; trifluoroacetic acid; sodium hydroxide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; dichloromethane; water; 1: Suzuki Coupling;