N-[6-(3-amino-4-fluorophenoxy)imidazo[1,2-b]pyridazin-2-yl]cyclopropanecarboxamide

Base Information

Chemical Name:N-[6-(3-amino-4-fluorophenoxy)imidazo[1,2-b]pyridazin-2-yl]cyclopropanecarboxamide
CAS No.:1005781-39-4
Molecular Formula:C₁₆H₁₄FN₅O₂
Molecular Weight:327.318
Hs Code.:

Synonyms:N-[6-(3-amino-4-fluorophenoxy)imidazo[1,2-b]pyridazin-2-yl]cyclopropanecarboxamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-[6-(3-amino-4-fluorophenoxy)imidazo[1,2-b]pyridazin-2-yl]cyclopropanecarboxamide

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Technology Process of N-[6-(3-amino-4-fluorophenoxy)imidazo[1,2-b]pyridazin-2-yl]cyclopropanecarboxamide

There total 3 articles about N-[6-(3-amino-4-fluorophenoxy)imidazo[1,2-b]pyridazin-2-yl]cyclopropanecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 62257-16-3
5-hydroxy-2-fluoroaniline

: 1005787-88-1
N-(6-iodoimidazo[1,2-b]pyridazin-2-yl)cyclopropanecarboxamide

: 1005781-39-4
N-[6-(3-amino-4-fluorophenoxy)imidazo[1,2-b]pyridazin-2-yl]cyclopropanecarboxamide

Guidance literature:: With potassium carbonate; In tetrahydrofuran; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 1005785-69-2
ethyl (6-iodoimidazo[1,2-b]pyridazin-2-yl)carbamate

: 1005781-39-4
N-[6-(3-amino-4-fluorophenoxy)imidazo[1,2-b]pyridazin-2-yl]cyclopropanecarboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: barium hydroxide octahydrate; water / 1-methyl-pyrrolidin-2-one / 8 h / 120 °C

2: N,N-dimethyl acetamide / 4 h / 20 °C

3: potassium carbonate / N,N-dimethyl-formamide / 24 h / 150 °C

With barium hydroxide octahydrate; water; potassium carbonate; In 1-methyl-pyrrolidin-2-one; N,N-dimethyl acetamide; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2013.01.074

Reference yield:

: 1005785-71-6
6-iodo-imidazo[1,2-b]pyridazin-2-ylamine

: 1005781-39-4
N-[6-(3-amino-4-fluorophenoxy)imidazo[1,2-b]pyridazin-2-yl]cyclopropanecarboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: N,N-dimethyl acetamide / 4 h / 20 °C

2: potassium carbonate / N,N-dimethyl-formamide / 24 h / 150 °C

With potassium carbonate; In N,N-dimethyl acetamide; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2013.01.074