62257-16-3

Basic information

• Product Name: 3-Amino-4-fluorophenol
• Synonyms: 3-Amino-4-fluorophenol;6004 3-AMINO-4-FLUORO PHENOL;3-Amino-4-fluorophenol 99%;Phenol,3-aMino-4-fluoro-;2-Fluoro-5-hydroxyaniline
• CAS NO: 62257-16-3
• Molecular Formula: C₆H₆FNO
• Molecular Weight: 127.12
• EINECS: 1308068-626-2
• Product Categories: Phenol&Thiophenol&Mercaptan
• Mol File: 62257-16-3.mol
• Article Data: 16

Chemical Properties

• Melting Point: 141-143 °C
• Boiling Point: 269.3 °C at 760 mmHg
• Flash Point: 116.7 °C
• Appearance: /
• Density: 1.347 g/cm³
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: 10.03±0.18(Predicted)
• CAS DataBase Reference: 3-Amino-4-fluorophenol(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Amino-4-fluorophenol(62257-16-3)
• EPA Substance Registry System: 3-Amino-4-fluorophenol(62257-16-3)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• Hazardous Substances Data: 62257-16-3(Hazardous Substances Data)

Usage

General Description

3-Amino-4-fluorophenol is an organic chemical compound with the molecular formula C6H6FNO. It is an aromatic amine that consists of a phenol group substituted with an amino and a fluorine group. 3-Amino-4-fluorophenol is commonly used as an intermediate in the synthesis of pharmaceuticals, dyes, and other organic compounds. It is known for its reactivity and is often used in organic chemistry reactions to introduce the amino and fluorine functional groups into other molecules. In addition, 3-Amino-4-fluorophenol has potential applications in the development of new materials and chemical technologies. However, it is important to handle this compound with care as it may pose some health and environmental hazards.

Upstream product

• 75001-47-7 N-(5-amino-2-fluorophenyl)acetamide 
• 1228996-49-3 2-fluoro-5-hydroxy-N-(trifluoroacetyl)aniline 
• 84478-88-6 2-chloro-4-fluoro-methoxycarbonyloxybenzene 
• 1996-41-4 2-chloro-4-fluorophenol 
• 2105-96-6 4-fluoro-3-nitrophenol 
• 84478-75-1 2-chloro-4-fluoro-5-nitrophenol 
• 454-07-9 N-(2-fluoro-5-nitrophenyl)acetamide 
• 369-36-8 6-fluoro-3-nitroaniline 
• 84478-89-7 2-chloro-4-fluoro-5-nitro-methoxycarbonyloxybenzene 

Downstream Products

• 1020173-02-7 5-(3-amino-4-fluorophenoxy)picolinonitrile 
• 1020173-04-9 2-fluoro-5-(2-(methylthio)pyrimidin-4-yloxy)benzenamine 
• 1020173-08-3 2-fluoro-5-(6-(trifluoromethyl)pyridin-3-yloxy)benzenamine 
• 1020173-36-7 5-(4-(1-(4-methoxybenzyl)-1H-pyrazol-4-yl)pyrimidin-2-yloxy)-2-fluorobenzenamine 
• 143661-65-8 2-fluoro-5-cyclopentyloxyaniline 
• 932708-75-3 2-(2,4-dichlorobenzyl)-N-(2-fluoro-5-hydroxyphenyl)-3-oxobutyramide 
• 1020172-92-2 5-(5-chloropyridin-3-yloxy)-2-fluoroaniline 
• 1005781-39-4 N-[6-(3-amino-4-fluorophenoxy)imidazo[1,2-b]pyridazin-2-yl]cyclopropanecarboxamide 
• 1005779-75-8 N-[6-(3-amino-4-fluorophenoxy)imidazo[1,2-b]pyridazin-2-yl]-2-methylcyclopropanecarboxamide 
• 1005784-06-4 N-[6-(3-amino-4-fluorophenoxy)imidazo[1,2-b]pyridazin-2-yl]acetamide 
• 1125632-14-5 2-chloro-3-(1-cyanocyclopropyl)-N-(2-fluoro-5-hydroxyphenyl)benzamide 
• 1125632-07-6 tert-butyl (5-{[2-(acetylamino)[1,3]thiazolo[5,4-b]pyridin-5-yl]oxy}-2-fluorophenyl)carbamate 
• 1125632-09-8 N-[5-(3-amino-4-fluorophenoxy)[1,3]thiazolo[5,4-b]pyridin-2-yl]acetamide 
• 1125633-37-5 N-(5-{[2-(acetylamino)[1,3]thiazolo[5,4-b]pyridin-5-yl]oxy}-2-fluorophenyl)-2-chloro-3-(1-cyanocyclopropyl)benzamide 

Relevant articles and documents

POLYAROMATIC UREA DERIVATIVES AND THEIR USE IN THE TREATMENT OF MUSCLE DISEASES

The current invention provides urea derivatives, in particular compounds having the core structure heteroaryl-NH-CO-NH-aryl-O- heteroaryl, for use in treating, ameliorating, delaying, curing and/ or preventing a disease or condition associated with muscle cells and/or satellite cells, such as Duchenne muscular dystrophy, Becker muscular dystrophy, cachexia or sarcopenia.

Preparation method of 3-amino-4-fluorophenol

The invention provides a preparation method of 3-amino-4-fluorophenol. The preparation method comprises the following steps of mixing 2-bromo-2-fluoro-5-nitrophenoxy ethyl formate, an alkaline matter, a hydrogenation catalyst and an organic solvent, so as to obtain a mixture; introducing hydrogen into the mixture to perform hydrogenation reaction under the sealing condition, so as to obtain the 3-amino-4-fluorophenol, wherein before the hydrogen is introduced, the air in a sealed system is exhausted out. The preparation method has the advantages that the synthesis route is short, and fewer steps are adopted; only one-step reaction is required for the 2-bromo-2-fluoro-5-nitrophenoxy ethyl formate to synthesize the 3-amino-4-fluorophenol, and the amount of three wastes produced in the reaction process is fewer; by simply separating the synthesized product, the product with purity not less than 99% can be obtained, and the yield rate is high.

Fluorinated rhodamines as photostable fluorescent dyes for labelling and imaging techniques

The present invention relates to novel fluorinated 3,6-diaminoxanthene compounds derived from the basic structural formula (I) and to their uses as photostable fluorescent dyes, e.g. for immunostainings and spectroscopic and microscopic applications, in particular in conventional microscopy, stimulated emission depletion (STED) reversible saturable optically linear fluorescent transitions (RESOLFT) microscopy, and fluorescence correlation spectroscopy. The claimed compounds are also useful as molecular probes in various spectroscopic applications.