5-methyl-N-(2-(trimethylsilyl)ethynyl)-N-(p-tosyl)hexa-3,4-dien-1-amine

Base Information

Chemical Name:5-methyl-N-(2-(trimethylsilyl)ethynyl)-N-(p-tosyl)hexa-3,4-dien-1-amine
CAS No.:1301664-11-8
Molecular Formula:C₁₉H₂₇NO₂SSi
Molecular Weight:361.58
Hs Code.:

Synonyms:5-methyl-N-(2-(trimethylsilyl)ethynyl)-N-(p-tosyl)hexa-3,4-dien-1-amine

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Chemical Property of 5-methyl-N-(2-(trimethylsilyl)ethynyl)-N-(p-tosyl)hexa-3,4-dien-1-amine

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Technology Process of 5-methyl-N-(2-(trimethylsilyl)ethynyl)-N-(p-tosyl)hexa-3,4-dien-1-amine

There total 5 articles about 5-methyl-N-(2-(trimethylsilyl)ethynyl)-N-(p-tosyl)hexa-3,4-dien-1-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 18243-59-9
(2-bromoethynyl)trimethylsilane

: 156900-59-3
5-methyl-N-(p-tosyl)hexa-3,4-dien-1-amine

: 1301664-11-8
5-methyl-N-(2-(trimethylsilyl)ethynyl)-N-(p-tosyl)hexa-3,4-dien-1-amine

Guidance literature:: With iron(III) chloride hexahydrate; potassium carbonate; N,N`-dimethylethylenediamine; In toluene; at 90 ℃; for 16h; Inert atmosphere;
DOI:10.1021/ol201041h

Reference yield:

: 54795-27-6
5-methyl-3,4-hexadien-1-ol

: 1301664-11-8
5-methyl-N-(2-(trimethylsilyl)ethynyl)-N-(p-tosyl)hexa-3,4-dien-1-amine

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere

2: potassium carbonate / acetonitrile / 16 h / Reflux; Inert atmosphere

3: iron(III) chloride hexahydrate; potassium carbonate; N,N`-dimethylethylenediamine / toluene / 16 h / 90 °C / Inert atmosphere

With iron(III) chloride hexahydrate; potassium carbonate; triethylamine; N,N`-dimethylethylenediamine; In tetrahydrofuran; toluene; acetonitrile;
DOI:10.1021/ol201041h

Reference yield:

: 30333-01-8
5-methylhexa-3,4-dienoic acid ethyl ester

: 1301664-11-8
5-methyl-N-(2-(trimethylsilyl)ethynyl)-N-(p-tosyl)hexa-3,4-dien-1-amine

Guidance literature:: Multi-step reaction with 4 steps

1: lithium aluminium tetrahydride / diethyl ether / 1 h / 0 °C / Inert atmosphere

2: triethylamine / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere

3: potassium carbonate / acetonitrile / 16 h / Reflux; Inert atmosphere

4: iron(III) chloride hexahydrate; potassium carbonate; N,N`-dimethylethylenediamine / toluene / 16 h / 90 °C / Inert atmosphere

With lithium aluminium tetrahydride; iron(III) chloride hexahydrate; potassium carbonate; triethylamine; N,N`-dimethylethylenediamine; In tetrahydrofuran; diethyl ether; toluene; acetonitrile;
DOI:10.1021/ol201041h