(2S,4R)-1-benzyloxycarbonyl-4-methanesulfonyloxy-2-[(2-ureidoethyl)oxymethyl]pyrrolidine

Base Information

Chemical Name:(2S,4R)-1-benzyloxycarbonyl-4-methanesulfonyloxy-2-[(2-ureidoethyl)oxymethyl]pyrrolidine
CAS No.:117811-83-3
Molecular Formula:C₁₇H₂₅N₃O₇S
Molecular Weight:415.467
Hs Code.:

Synonyms:(2S,4R)-1-benzyloxycarbonyl-4-methanesulfonyloxy-2-[(2-ureidoethyl)oxymethyl]pyrrolidine

Suppliers and Price of (2S,4R)-1-benzyloxycarbonyl-4-methanesulfonyloxy-2-[(2-ureidoethyl)oxymethyl]pyrrolidine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S,4R)-1-benzyloxycarbonyl-4-methanesulfonyloxy-2-[(2-ureidoethyl)oxymethyl]pyrrolidine

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (2S,4R)-1-benzyloxycarbonyl-4-methanesulfonyloxy-2-[(2-ureidoethyl)oxymethyl]pyrrolidine

There total 10 articles about (2S,4R)-1-benzyloxycarbonyl-4-methanesulfonyloxy-2-[(2-ureidoethyl)oxymethyl]pyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (2S,4R)-1-benzyloxycarbonyl-4-methanesulfonyloxy-2-[(ureidocarbonylmethyl)oxymethyl]pyrrolidine

: 117811-83-3
(2S,4R)-1-benzyloxycarbonyl-4-methanesulfonyloxy-2-[(2-ureidoethyl)oxymethyl]pyrrolidine

Guidance literature:: With sodium borohydrid; trifluoroborane diethyl ether; In tetrahydrofuran; methanol; chloroform;

Reference yield:

: 64187-48-0
methyl (2S,4R)-1-benzyloxycarbonyl-4-hydroxypyrrolidine-2-carboxylate

: 117811-83-3
(2S,4R)-1-benzyloxycarbonyl-4-methanesulfonyloxy-2-[(2-ureidoethyl)oxymethyl]pyrrolidine

Guidance literature:: Multi-step reaction with 8 steps

1: Et₃N / ethyl acetate / 0.5 h / 0 - 5 °C

2: NaBH₄ / tetrahydrofuran; ethanol / 2 h / 25 - 30 °C

3: t-BuOK / tetrahydrofuran / 1 h / -10 - -5 °C

4: 2N aq. NaOH / tetrahydrofuran / 20 - 25 °C

5: Et₃N / tetrahydrofuran

6: NH₃ / tetrahydrofuran / -10 °C

7: NaBH₄, BF₃*Et₂O / tetrahydrofuran / 2 h / Ambient temperature

8: tetrahydrofuran; H₂O / 1 h / 40 - 50 °C

With sodium hydroxide; sodium tetrahydroborate; boron trifluoride diethyl etherate; potassium tert-butylate; ammonia; triethylamine; In tetrahydrofuran; ethanol; water; ethyl acetate;
DOI:10.1016/S0968-0896(97)00142-9

Reference yield:

: 117811-78-6
methyl (2S,4R)-1-benzyloxycarbonyl-4-methanesulfonyloxypyrrolidine-2-carboxylate

: 117811-83-3
(2S,4R)-1-benzyloxycarbonyl-4-methanesulfonyloxy-2-[(2-ureidoethyl)oxymethyl]pyrrolidine

Guidance literature:: Multi-step reaction with 7 steps

1: NaBH₄ / tetrahydrofuran; ethanol / 2 h / 25 - 30 °C

2: t-BuOK / tetrahydrofuran / 1 h / -10 - -5 °C

3: 2N aq. NaOH / tetrahydrofuran / 20 - 25 °C

4: Et₃N / tetrahydrofuran

5: NH₃ / tetrahydrofuran / -10 °C

6: NaBH₄, BF₃*Et₂O / tetrahydrofuran / 2 h / Ambient temperature

7: tetrahydrofuran; H₂O / 1 h / 40 - 50 °C

With sodium hydroxide; sodium tetrahydroborate; boron trifluoride diethyl etherate; potassium tert-butylate; ammonia; triethylamine; In tetrahydrofuran; ethanol; water;
DOI:10.1016/S0968-0896(97)00142-9