2-(3-chloro-4-(2-methyl-4-nitro-1H-benzo[d]imidazol-5-yloxy)phenyl)acetic acid

Base Information

Chemical Name:2-(3-chloro-4-(2-methyl-4-nitro-1H-benzo[d]imidazol-5-yloxy)phenyl)acetic acid
CAS No.:1080522-31-1
Molecular Formula:C₁₆H₁₂ClN₃O₅
Molecular Weight:361.741
Hs Code.:

Synonyms:2-(3-chloro-4-(2-methyl-4-nitro-1H-benzo[d]imidazol-5-yloxy)phenyl)acetic acid

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Chemical Property of 2-(3-chloro-4-(2-methyl-4-nitro-1H-benzo[d]imidazol-5-yloxy)phenyl)acetic acid

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Technology Process of 2-(3-chloro-4-(2-methyl-4-nitro-1H-benzo[d]imidazol-5-yloxy)phenyl)acetic acid

There total 3 articles about 2-(3-chloro-4-(2-methyl-4-nitro-1H-benzo[d]imidazol-5-yloxy)phenyl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1080522-30-0
5-fluoro-2-methyl-4-nitro-1H-benzo[d]imidazole

: 33697-81-3
(3-chloro-4-hydroxy-phenyl)-acetic acid

: 1080522-31-1
2-(3-chloro-4-(2-methyl-4-nitro-1H-benzo[d]imidazol-5-yloxy)phenyl)acetic acid

Guidance literature:: 5-fluoro-2-methyl-4-nitro-1H-benzo[d]imidazole; (3-chloro-4-hydroxy-phenyl)-acetic acid; With potassium fluoride on basic alumina; 18-crown-6 ether; In dimethyl sulfoxide; at 80 ℃; for 20h;

With hydrogenchloride; In water; dimethyl sulfoxide; pH=5;

Reference yield:

: 118469-15-1
5-fluoro-2-methyl-1H-benzo[d]imidazole

: 1080522-31-1
2-(3-chloro-4-(2-methyl-4-nitro-1H-benzo[d]imidazol-5-yloxy)phenyl)acetic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: sulfuric acid; nitric acid / 1 h / 0 °C

1.2: 0 °C

2.1: potassium fluoride on basic alumina / 18-crown-6 ether / dimethyl sulfoxide / 20 h / 80 °C

2.2: pH 5

With sulfuric acid; potassium fluoride on basic alumina; nitric acid; 18-crown-6 ether; In dimethyl sulfoxide;

Reference yield:

: 367-31-7
4-fluoro-1,2-phenylenediamine

: 1080522-31-1
2-(3-chloro-4-(2-methyl-4-nitro-1H-benzo[d]imidazol-5-yloxy)phenyl)acetic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogenchloride / ethanol; water / 0.5 h / 50 °C / Heating / reflux

1.2: 20 °C

2.1: sulfuric acid; nitric acid / 1 h / 0 °C

2.2: 0 °C

3.1: potassium fluoride on basic alumina / 18-crown-6 ether / dimethyl sulfoxide / 20 h / 80 °C

3.2: pH 5

With hydrogenchloride; sulfuric acid; potassium fluoride on basic alumina; nitric acid; 18-crown-6 ether; In ethanol; water; dimethyl sulfoxide;