dimethyl 2'-methoxy-2,5-dihydro-[1,1'-biphenyl]-3,4-dicarboxylate

Base Information

• Chemical Name: dimethyl 2'-methoxy-2,5-dihydro-[1,1'-biphenyl]-3,4-dicarboxylate
• CAS No.: 1451077-80-7
• Molecular Formula: C₁₇H₁₈O₅
• Molecular Weight: 302.327
• Mol file: 1451077-80-7.mol

Synonyms:dimethyl 2'-methoxy-2,5-dihydro-[1,1'-biphenyl]-3,4-dicarboxylate

Chemical Property of dimethyl 2'-methoxy-2,5-dihydro-[1,1'-biphenyl]-3,4-dicarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of dimethyl 2'-methoxy-2,5-dihydro-[1,1'-biphenyl]-3,4-dicarboxylate

There total 3 articles about dimethyl 2'-methoxy-2,5-dihydro-[1,1'-biphenyl]-3,4-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

4-(2-methoxyphenyl)-1,3-butadiene (79554-84-0,60573-56-0) + dimethyl acetylenedicarboxylate (762-42-5) → dimethyl 2'-methoxy-2,5-dihydro-[1,1'-biphenyl]-3,4-dicarboxylate (1451077-80-7)

Guidance literature:

In toluene; at 80 ℃; for 8h; Inert atmosphere; Schlenk technique;

DOI:10.1016/j.catcom.2013.06.023

Reference yield: 43.0%

(E)-2-(2-methoxyphenyl)-4-(trimethylsilyl)but-2-en-1-ol + dimethyl acetylenedicarboxylate (762-42-5) → dimethyl 2'-methoxy-2,5-dihydro-[1,1'-biphenyl]-3,4-dicarboxylate (1451077-80-7)

Guidance literature:

With iron(III) sulfate; In tetrahydrofuran; at 80 ℃; for 12h; Inert atmosphere; Schlenk technique;

DOI:10.1021/acs.orglett.0c01690

Reference yield:

4-(2-methoxyphenyl)-4-vinyl-1,3-dioxolan-2-one (1459246-65-1) → dimethyl 2'-methoxy-2,5-dihydro-[1,1'-biphenyl]-3,4-dicarboxylate (1451077-80-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 2,2':6,2''-terpyridine; palladium diacetate; water; 1,1,1,3,3,3-hexamethyl-disilazane / tetrahydrofuran / 24 h / 60 °C / Inert atmosphere; Schlenk technique; Sealed tube

2: iron(III) sulfate / tetrahydrofuran / 12 h / 80 °C / Inert atmosphere; Schlenk technique

With 2,2':6,2''-terpyridine; iron(III) sulfate; water; palladium diacetate; 1,1,1,3,3,3-hexamethyl-disilazane; In tetrahydrofuran;

DOI:10.1021/acs.orglett.0c01690

upstream raw materials:

4-(2-methoxyphenyl)-1,3-butadiene

dimethyl acetylenedicarboxylate

4-(2-methoxyphenyl)-4-vinyl-1,3-dioxolan-2-one