(2-dimethylamino-6-methoxy-benzo[b]thiophen-3-yl)-(4-fluoro-phenyl)-methanone

Base Information

• Chemical Name: (2-dimethylamino-6-methoxy-benzo[b]thiophen-3-yl)-(4-fluoro-phenyl)-methanone
• CAS No.: 243845-88-7
• Molecular Formula: C₁₈H₁₆FNO₂S
• Molecular Weight: 329.395

Synonyms:(2-dimethylamino-6-methoxy-benzo[b]thiophen-3-yl)-(4-fluoro-phenyl)-methanone

Chemical Property of (2-dimethylamino-6-methoxy-benzo[b]thiophen-3-yl)-(4-fluoro-phenyl)-methanone

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

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Technology Process of (2-dimethylamino-6-methoxy-benzo[b]thiophen-3-yl)-(4-fluoro-phenyl)-methanone

There total 1 articles about (2-dimethylamino-6-methoxy-benzo[b]thiophen-3-yl)-(4-fluoro-phenyl)-methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

4-fluorobenzoyl chloride (403-43-0) + 6-methoxy-N,N-dimethylbenzo[b]thiophen-2-amine (111359-29-6) → (2-dimethylamino-6-methoxy-benzo[b]thiophen-3-yl)-(4-fluoro-phenyl)-methanone (243845-88-7)

Guidance literature:

In chlorobenzene; at 20 ℃;

DOI:10.1016/S0040-4039(99)00955-7

Reference yield: 97.0%

1-piperidinoethanol (3040-44-6) + (2-dimethylamino-6-methoxy-benzo[b]thiophen-3-yl)-(4-fluoro-phenyl)-methanone (243845-88-7) → [2-dimethylamino-6-methoxybenzothien-3-yl] [4-[2-(1-piperidinyl)ethoxy]phenyl]-methanone (165742-76-7)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 0.25h;

DOI:10.1016/S0040-4039(99)00955-7

Reference yield: 97.0%

1-(hydroxyethyl)piperidine sodium alkoxide (62315-59-7) + (2-dimethylamino-6-methoxy-benzo[b]thiophen-3-yl)-(4-fluoro-phenyl)-methanone (243845-88-7) → [2-dimethylamino-6-methoxybenzothien-3-yl] [4-[2-(1-piperidinyl)ethoxy]phenyl]-methanone (165742-76-7)

Guidance literature:

In N,N-dimethyl-formamide; at 20 ℃; for 0.25h;

DOI:10.1016/S0040-4039(99)00955-7

upstream raw materials:

4-fluorobenzoyl chloride

6-methoxy-N,N-dimethylbenzo[b]thiophen-2-amine

Downstream raw materials:

[2-dimethylamino-6-methoxybenzothien-3-yl] [4-[2-(1-piperidinyl)ethoxy]phenyl]-methanone

6-methoxy-2-(4-methoxyphenyl)-3-(4-fluorobenzoyl)benzo[b]thiophene

(4-fluoro-phenyl)-[2-(4-fluoro-phenyl)-6-methoxy-benzo[b]thiophen-3-yl]-methanone

2-(4-methoxyphenyl)benzo[b]thiophen-3-yl 4-[2-(1-piperidyl)ethoxy]phenyl ketone

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