dimethyl phenylene-1,4-bis(methyl)phosphinate

Base Information

• Chemical Name: dimethyl phenylene-1,4-bis(methyl)phosphinate
• CAS No.: 10580-44-6
• Molecular Formula: C₁₀H₁₆O₄P₂
• Molecular Weight: 262.182
• Mol file: 10580-44-6.mol

Synonyms:dimethyl phenylene-1,4-bis(methyl)phosphinate

Chemical Property of dimethyl phenylene-1,4-bis(methyl)phosphinate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of dimethyl phenylene-1,4-bis(methyl)phosphinate

There total 3 articles about dimethyl phenylene-1,4-bis(methyl)phosphinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

1.4-dibromobenzene (106-37-6) + methyl hypophosphorous acid methyl ester (16391-06-3) → dimethyl phenylene-1,4-bis(methyl)phosphinate (10580-44-6)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine; In 1,4-dioxane; at 60 ℃; for 96h; Schlenk technique; Inert atmosphere;

DOI:10.1002/anie.201800884

Reference yield:

1,4-Bis(diphenylphosphino)benzene (1179-06-2) → dimethyl phenylene-1,4-bis(methyl)phosphinate (10580-44-6)

Guidance literature:

Multi-step reaction with 2 steps

1: (i) PCl₃, (ii) /BRN= 1098229/, Et₃N, Et₂O, THF

2: benzene

In benzene;

DOI:10.1021/jo01282a020

Reference yield:

p-C6H4(P(OMe)2)2 (10498-59-6) + methyl iodide (74-88-4) → dimethyl phenylene-1,4-bis(methyl)phosphinate (10580-44-6)

Guidance literature:

In benzene;

DOI:10.1021/jo01282a020

upstream raw materials:

p-C₆H₄(P(OMe)2)2

methyl iodide

1,4-Bis(diphenylphosphino)benzene

1.4-dibromobenzene

Downstream raw materials:

phenylene-1,4-bis(methyl)phosphinic acid

Refernces

• 1、 Hynek, Jan,Brázda, Petr,Rohlí?ek, Jan,Londesborough, Michael G. S.,Demel, Jan. "Phosphinic Acid Based Linkers: Building Blocks in Metal–Organic Framework Chemistry". supporting information. p. 5016 - 5019. Retrieved 2018/03/27.