N-benzyl-2,3,4,5-tetrahydro-7,8-dimethoxy-1-phenyl-1,4-methano-1H-3-benzazepine-2,5-dione

Base Information

Chemical Name:N-benzyl-2,3,4,5-tetrahydro-7,8-dimethoxy-1-phenyl-1,4-methano-1H-3-benzazepine-2,5-dione
CAS No.:135714-89-5
Molecular Formula:C₂₆H₂₃NO₄
Molecular Weight:413.473
Hs Code.:

Synonyms:N-benzyl-2,3,4,5-tetrahydro-7,8-dimethoxy-1-phenyl-1,4-methano-1H-3-benzazepine-2,5-dione

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Chemical Property of N-benzyl-2,3,4,5-tetrahydro-7,8-dimethoxy-1-phenyl-1,4-methano-1H-3-benzazepine-2,5-dione

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Technology Process of N-benzyl-2,3,4,5-tetrahydro-7,8-dimethoxy-1-phenyl-1,4-methano-1H-3-benzazepine-2,5-dione

There total 10 articles about N-benzyl-2,3,4,5-tetrahydro-7,8-dimethoxy-1-phenyl-1,4-methano-1H-3-benzazepine-2,5-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 135714-88-4
N-benzyl 3-bromo-1,2,3,4-tetrahydro-6,7-dimethoxy-4-oxo-1-phenylnaphthalene-1-carboxamide

: 135714-89-5
N-benzyl-2,3,4,5-tetrahydro-7,8-dimethoxy-1-phenyl-1,4-methano-1H-3-benzazepine-2,5-dione

Guidance literature:: With sodium; In methanol; for 2.5h; Heating;

Reference yield:

: 91-16-7
1,2-dimethoxybenzene

: 135714-89-5
N-benzyl-2,3,4,5-tetrahydro-7,8-dimethoxy-1-phenyl-1,4-methano-1H-3-benzazepine-2,5-dione

Guidance literature:: Multi-step reaction with 8 steps

1: 1) 98percent H₂SO₄, gl. acetic acid / 1) 70 deg C, 1.5 h, 2) reflux, overnight

2: 1) EtONa, 2) hexamethylphosphoramide / 1) THF, 0.5 h, 2) THF, rt, overnight

3: 73 percent / NaOH / ethanol; H₂O / Heating

4: 60 percent / polyphosphoric acid / 6 h / Ambient temperature

5: 96 percent / NaOH / ethanol; H₂O / Heating

6: 1) Et₃N, 2-chloro-N-methylpyridinium iodide / 1) acetonitrile, 0.5 h, 2) 0.5 h

7: 82 percent / phenyltrimethylammonium tribromide / tetrahydrofuran / 1) 0 deg C, 0.5 h, 2) 1 h, 20 deg C

8: 73 percent / Na / methanol / 2.5 h / Heating

With N,N,N,N,N,N-hexamethylphosphoric triamide; sodium hydroxide; PPA; sulfuric acid; 2-chloro-1-methyl-pyridinium iodide; sodium ethanolate; sodium; phenyltrimethylammonium tribromide; acetic acid; triethylamine; In tetrahydrofuran; methanol; ethanol; water;

Reference yield:

: 135714-86-2
1,2,3,4-tetrahydro-6,7-dimethoxy-4-oxo-1-phenylnaphthalene-1-carboxylic acid

: 135714-89-5
N-benzyl-2,3,4,5-tetrahydro-7,8-dimethoxy-1-phenyl-1,4-methano-1H-3-benzazepine-2,5-dione

Guidance literature:: Multi-step reaction with 3 steps

1: 1) Et₃N, 2-chloro-N-methylpyridinium iodide / 1) acetonitrile, 0.5 h, 2) 0.5 h

2: 82 percent / phenyltrimethylammonium tribromide / tetrahydrofuran / 1) 0 deg C, 0.5 h, 2) 1 h, 20 deg C

3: 73 percent / Na / methanol / 2.5 h / Heating

With 2-chloro-1-methyl-pyridinium iodide; sodium; phenyltrimethylammonium tribromide; triethylamine; In tetrahydrofuran; methanol;