2-(4-fluorophenyl)-5-(11-formyl-6H-pyrido[2',3':5,6][1,3]oxazino[3,4-a]indol-2-yl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide

Base Information

Chemical Name:2-(4-fluorophenyl)-5-(11-formyl-6H-pyrido[2',3':5,6][1,3]oxazino[3,4-a]indol-2-yl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide
CAS No.:1427034-71-6
Molecular Formula:C₃₃H₂₅FN₄O₆S
Molecular Weight:624.649
Hs Code.:

Synonyms:2-(4-fluorophenyl)-5-(11-formyl-6H-pyrido[2',3':5,6][1,3]oxazino[3,4-a]indol-2-yl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide

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Chemical Property of 2-(4-fluorophenyl)-5-(11-formyl-6H-pyrido[2',3':5,6][1,3]oxazino[3,4-a]indol-2-yl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide

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Technology Process of 2-(4-fluorophenyl)-5-(11-formyl-6H-pyrido[2',3':5,6][1,3]oxazino[3,4-a]indol-2-yl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide

There total 10 articles about 2-(4-fluorophenyl)-5-(11-formyl-6H-pyrido[2',3':5,6][1,3]oxazino[3,4-a]indol-2-yl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1333340-17-2
2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzofuran-3-carboxamide

: 1427034-70-5
2-chloro-6H-pyrido[2',3':5,6][1,3]oxazino[3,4-a]indole-11-carbaldehyde

: 1427034-71-6
2-(4-fluorophenyl)-5-(11-formyl-6H-pyrido[2',3':5,6][1,3]oxazino[3,4-a]indol-2-yl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide

Guidance literature:: With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium phosphate tribasic trihydrate; XPhos; In 1,4-dioxane; water; at 100 ℃; for 16h; Inert atmosphere;

Reference yield:

: 1427035-55-9
2-chloro-6H-pyrido[2',3':5,6][1,3]oxazino[3,4-a]indole-11-carbonitrile

: 1427034-71-6
2-(4-fluorophenyl)-5-(11-formyl-6H-pyrido[2',3':5,6][1,3]oxazino[3,4-a]indol-2-yl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: diisobutylaluminium hydride / toluene / 6 h / -78 °C / Inert atmosphere

2: XPhos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium phosphate tribasic trihydrate / 1,4-dioxane; water / 16 h / 100 °C / Inert atmosphere

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium phosphate tribasic trihydrate; diisobutylaluminium hydride; XPhos; In 1,4-dioxane; water; toluene;

Reference yield:

: 1333340-15-0
ethyl 6-amino-5-bromo-2-(4-fluorophenyl)benzofuran-3-carboxylate

: 1427034-71-6
2-(4-fluorophenyl)-5-(11-formyl-6H-pyrido[2',3':5,6][1,3]oxazino[3,4-a]indol-2-yl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: pyridine / dichloromethane / 0 - 20 °C

2.1: water; lithium hydroxide monohydrate / 1,4-dioxane / 3 h / 100 °C

3.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 2 h / 20 °C

4.1: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 80 - 90 °C / Inert atmosphere

5.1: potassium acetate / 1,4-dioxane / 4 h / 20 °C / Inert atmosphere

5.2: 1.5 h / 130 °C / Inert atmosphere

6.1: XPhos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium phosphate tribasic trihydrate / 1,4-dioxane; water / 16 h / 100 °C / Inert atmosphere

With pyridine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; lithium hydroxide monohydrate; potassium phosphate tribasic trihydrate; water; potassium acetate; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; potassium iodide; XPhos; In 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide;