pyrrolidine-1-carboxylic acid-{3-[4-(3-cyano-4-pyrrolidin-1-ylphenyl)pyrimidin-2-ylamino]phenyl}amide

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Chemical Name:pyrrolidine-1-carboxylic acid-{3-[4-(3-cyano-4-pyrrolidin-1-ylphenyl)pyrimidin-2-ylamino]phenyl}amide
CAS No.:1356225-62-1
Molecular Formula:C₂₆H₂₇N₇O
Molecular Weight:453.547
Hs Code.:

Synonyms:pyrrolidine-1-carboxylic acid-{3-[4-(3-cyano-4-pyrrolidin-1-ylphenyl)pyrimidin-2-ylamino]phenyl}amide

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Chemical Property of pyrrolidine-1-carboxylic acid-{3-[4-(3-cyano-4-pyrrolidin-1-ylphenyl)pyrimidin-2-ylamino]phenyl}amide

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Technology Process of pyrrolidine-1-carboxylic acid-{3-[4-(3-cyano-4-pyrrolidin-1-ylphenyl)pyrimidin-2-ylamino]phenyl}amide

There total 5 articles about pyrrolidine-1-carboxylic acid-{3-[4-(3-cyano-4-pyrrolidin-1-ylphenyl)pyrimidin-2-ylamino]phenyl}amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 21.0%

: 702638-74-2
pyrrolidine-1-carboxylic acid (3-amino-phenyl)-amide

: 1356226-84-0
5-(2-chloro-pyrimidin-4-yl)-2-pyrrolidin-1-yl-benzonitrile

: 1356225-62-1
pyrrolidine-1-carboxylic acid-{3-[4-(3-cyano-4-pyrrolidin-1-ylphenyl)pyrimidin-2-ylamino]phenyl}amide

Guidance literature:: With sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; DavePhos; In 1,4-dioxane; at 100 ℃; for 0.166667h; Microwave irradiation;

Reference yield:

: 775351-57-0
2-fluoro-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-benzonitrile

: 1356225-62-1
pyrrolidine-1-carboxylic acid-{3-[4-(3-cyano-4-pyrrolidin-1-ylphenyl)pyrimidin-2-ylamino]phenyl}amide

Guidance literature:: Multi-step reaction with 3 steps

1: 1-methyl-pyrrolidin-2-one / 0.08 h / 140 °C / Microwave irradiation

2: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 0.17 h / 100 °C / Microwave irradiation

3: sodium t-butanolate / DavePhos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 0.17 h / 100 °C / Microwave irradiation

With sodium carbonate; sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tetrakis(triphenylphosphine) palladium⁽⁰⁾; DavePhos; In 1,4-dioxane; 1-methyl-pyrrolidin-2-one; water; 3: Buchwald-Hartwig reaction;

Reference yield:

: 35799-28-1
N-(3-nitrophenyl)pyrrolidine-1-carboxamide

: 1356225-62-1
pyrrolidine-1-carboxylic acid-{3-[4-(3-cyano-4-pyrrolidin-1-ylphenyl)pyrimidin-2-ylamino]phenyl}amide

Guidance literature:: Multi-step reaction with 2 steps

1: hydrazine hydrate / raney nickel / ethyl acetate; methanol / 16 h / 20 °C

2: sodium t-butanolate / DavePhos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 0.17 h / 100 °C / Microwave irradiation

With hydrazine hydrate; sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; DavePhos; In 1,4-dioxane; methanol; ethyl acetate; 2: Buchwald-Hartwig reaction;