N-(1-(2-bromo-6-fluorophenyl)-2-(tert-butylamino)-2-oxoethyl)-N-(4-methoxybenzyl)but-2-ynamide

Base Information

Chemical Name:N-(1-(2-bromo-6-fluorophenyl)-2-(tert-butylamino)-2-oxoethyl)-N-(4-methoxybenzyl)but-2-ynamide
CAS No.:1620003-49-7
Molecular Formula:C₂₄H₂₆BrFN₂O₃
Molecular Weight:489.384
Hs Code.:

Synonyms:N-(1-(2-bromo-6-fluorophenyl)-2-(tert-butylamino)-2-oxoethyl)-N-(4-methoxybenzyl)but-2-ynamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(1-(2-bromo-6-fluorophenyl)-2-(tert-butylamino)-2-oxoethyl)-N-(4-methoxybenzyl)but-2-ynamide

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Technology Process of N-(1-(2-bromo-6-fluorophenyl)-2-(tert-butylamino)-2-oxoethyl)-N-(4-methoxybenzyl)but-2-ynamide

There total 1 articles about N-(1-(2-bromo-6-fluorophenyl)-2-(tert-butylamino)-2-oxoethyl)-N-(4-methoxybenzyl)but-2-ynamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 590-93-2
2-Butynoic acid

: 119072-55-8,7188-38-7
tert-butylisonitrile

: 360575-28-6
2-bromo-6-fluorobenzaldehyde

: 2393-23-9
4-methoxy-benzylamine

: 1620003-49-7
N-(1-(2-bromo-6-fluorophenyl)-2-(tert-butylamino)-2-oxoethyl)-N-(4-methoxybenzyl)but-2-ynamide

Guidance literature:: With sodium sulfate; In methanol; at 20 ℃;
DOI:10.1021/ol5019079

Reference yield: 53.0%

: 1620003-49-7
N-(1-(2-bromo-6-fluorophenyl)-2-(tert-butylamino)-2-oxoethyl)-N-(4-methoxybenzyl)but-2-ynamide

: 1620003-75-9
1-(tert-butyl)-4-fluoro-1'-(4-methoxybenzyl)-3'-methylspiro[indoline-3,2'-pyrrole]-2,5'(1'H)-dione

Guidance literature:: With palladium diacetate; caesium carbonate; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene; In toluene; at 120 ℃; for 24h; Inert atmosphere;
DOI:10.1021/ol5019079