N-(3-{[2-(4-{[(3S)-3-hydroxypyrrolidin-1-yl]carbonyl}-1H-pyrrol-2-yl)pyridin-4-yl]oxy}phenyl)-3-methyl-2-furamide

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Chemical Name:N-(3-{[2-(4-{[(3S)-3-hydroxypyrrolidin-1-yl]carbonyl}-1H-pyrrol-2-yl)pyridin-4-yl]oxy}phenyl)-3-methyl-2-furamide
CAS No.:1268620-02-5
Molecular Formula:C₂₆H₂₄N₄O₅
Molecular Weight:472.5
Hs Code.:

Synonyms:N-(3-{[2-(4-{[(3S)-3-hydroxypyrrolidin-1-yl]carbonyl}-1H-pyrrol-2-yl)pyridin-4-yl]oxy}phenyl)-3-methyl-2-furamide

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Chemical Property of N-(3-{[2-(4-{[(3S)-3-hydroxypyrrolidin-1-yl]carbonyl}-1H-pyrrol-2-yl)pyridin-4-yl]oxy}phenyl)-3-methyl-2-furamide

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Technology Process of N-(3-{[2-(4-{[(3S)-3-hydroxypyrrolidin-1-yl]carbonyl}-1H-pyrrol-2-yl)pyridin-4-yl]oxy}phenyl)-3-methyl-2-furamide

There total 9 articles about N-(3-{[2-(4-{[(3S)-3-hydroxypyrrolidin-1-yl]carbonyl}-1H-pyrrol-2-yl)pyridin-4-yl]oxy}phenyl)-3-methyl-2-furamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 1268619-96-0
5-(4-{3-[(3-methyl-2-furoyl)amino]phenoxy}pyridin-2-yl)-1H-pyrrole-3-carboxylic acid

: 100243-39-8
3-hydroxypyrrolidine

: 1268620-02-5
N-(3-{[2-(4-{[(3S)-3-hydroxypyrrolidin-1-yl]carbonyl}-1H-pyrrol-2-yl)pyridin-4-yl]oxy}phenyl)-3-methyl-2-furamide

Guidance literature:: 5-(4-{3-[(3-methyl-2-furoyl)amino]phenoxy}pyridin-2-yl)-1H-pyrrole-3-carboxylic acid; 3-hydroxypyrrolidine; With N-ethyl-N,N-diisopropylamine; HATU; In water; N,N-dimethyl-formamide; at 20 ℃; for 0.333333h;

With hydrogenchloride; In water; N,N-dimethyl-formamide; pH=4 - 5;

Reference yield:

: 591-27-5
m-Hydroxyaniline

: 1268620-02-5
N-(3-{[2-(4-{[(3S)-3-hydroxypyrrolidin-1-yl]carbonyl}-1H-pyrrol-2-yl)pyridin-4-yl]oxy}phenyl)-3-methyl-2-furamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: caesium carbonate / dimethyl sulfoxide / 0.17 h

1.2: 1.5 h / 120 °C

2.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane / 18 h / 92 °C / Sealed vessel

3.1: hydrogenchloride; N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.17 h / 20 °C

3.2: 2 h / 50 °C

4.1: sodium hydroxide / water; tetrahydrofuran; methanol / 8 h / 68 °C

4.2: pH 3

5.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide; water / 0.33 h / 20 °C

5.2: pH 4 - 5

With hydrogenchloride; potassium carbonate; caesium carbonate; N-ethyl-N,N-diisopropylamine; HATU; sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

: 26452-80-2
2,4-dichloropyridine

: 1268620-02-5
N-(3-{[2-(4-{[(3S)-3-hydroxypyrrolidin-1-yl]carbonyl}-1H-pyrrol-2-yl)pyridin-4-yl]oxy}phenyl)-3-methyl-2-furamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: caesium carbonate / dimethyl sulfoxide / 0.17 h

1.2: 1.5 h / 120 °C

2.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane / 18 h / 92 °C / Sealed vessel

3.1: hydrogenchloride; N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.17 h / 20 °C

3.2: 2 h / 50 °C

4.1: sodium hydroxide / water; tetrahydrofuran; methanol / 8 h / 68 °C

4.2: pH 3

5.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide; water / 0.33 h / 20 °C

5.2: pH 4 - 5

With hydrogenchloride; potassium carbonate; caesium carbonate; N-ethyl-N,N-diisopropylamine; HATU; sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide;