4-Chloro-2-[(2-cyclohexyloxy-acetyl)-(2-hydroxy-phenyl)-amino]-benzoic acid

Base Information

• Chemical Name: 4-Chloro-2-[(2-cyclohexyloxy-acetyl)-(2-hydroxy-phenyl)-amino]-benzoic acid
• CAS No.: 191337-80-1
• Molecular Formula: C₂₁H₂₂ClNO₅
• Molecular Weight: 403.862

Synonyms:4-Chloro-2-[(2-cyclohexyloxy-acetyl)-(2-hydroxy-phenyl)-amino]-benzoic acid

Chemical Property of 4-Chloro-2-[(2-cyclohexyloxy-acetyl)-(2-hydroxy-phenyl)-amino]-benzoic acid

Chemical Property:

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Technology Process of 4-Chloro-2-[(2-cyclohexyloxy-acetyl)-(2-hydroxy-phenyl)-amino]-benzoic acid

There total 2 articles about 4-Chloro-2-[(2-cyclohexyloxy-acetyl)-(2-hydroxy-phenyl)-amino]-benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

2-(cyclohexyloxy)acetyl chloride (191337-81-2) + 4-chloro-N-(2-hydroxyphenyl)anthranilic acid (173410-19-0) → 4-Chloro-2-[(2-cyclohexyloxy-acetyl)-(2-hydroxy-phenyl)-amino]-benzoic acid (191337-80-1)

Guidance literature:

With 1H-imidazole; In dichloromethane;

DOI:10.1002/jhet.5570340221

Reference yield:

2-amino-phenol (95-55-6) → 4-Chloro-2-[(2-cyclohexyloxy-acetyl)-(2-hydroxy-phenyl)-amino]-benzoic acid (191337-80-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 33 percent / Cu

2: 70 percent / imidazole / CH₂Cl₂

With 1H-imidazole; copper; In dichloromethane;

DOI:10.1002/jhet.5570340221

Reference yield: 65.0%

4-Chloro-2-[(2-cyclohexyloxy-acetyl)-(2-hydroxy-phenyl)-amino]-benzoic acid (191337-80-1) → 2-Chloro-6-cyclohexyloxy-7-oxa-11b-aza-benzo[c]fluoren-5-one

Guidance literature:

With acetic anhydride; at 80 ℃;

DOI:10.1002/jhet.5570340221

upstream raw materials:

2-(cyclohexyloxy)acetyl chloride

4-chloro-N-(2-hydroxyphenyl)anthranilic acid

2-amino-phenol

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