4-Cyclopropyl-5-[2-(trifluoromethoxy)phenyl]-2,4-dihydro-3H-1,2,4-triazol-3-one

Base Information

• Chemical Name: 4-Cyclopropyl-5-[2-(trifluoromethoxy)phenyl]-2,4-dihydro-3H-1,2,4-triazol-3-one
• CAS No.: 1245940-70-8
• Molecular Formula: C₁₂H₁₀F₃N₃O₂
• Molecular Weight: 285.226

Synonyms:4-Cyclopropyl-5-[2-(trifluoromethoxy)phenyl]-2,4-dihydro-3H-1,2,4-triazol-3-one

Chemical Property of 4-Cyclopropyl-5-[2-(trifluoromethoxy)phenyl]-2,4-dihydro-3H-1,2,4-triazol-3-one

Chemical Property:

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Technology Process of 4-Cyclopropyl-5-[2-(trifluoromethoxy)phenyl]-2,4-dihydro-3H-1,2,4-triazol-3-one

There total 2 articles about 4-Cyclopropyl-5-[2-(trifluoromethoxy)phenyl]-2,4-dihydro-3H-1,2,4-triazol-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-Cyclopropyl-2-{[2-(trifluoromethoxy)phenyl]carbonyl}hydrazinecarboxamide (1245940-69-5) → 4-Cyclopropyl-5-[2-(trifluoromethoxy)phenyl]-2,4-dihydro-3H-1,2,4-triazol-3-one (1245940-70-8)

Guidance literature:

N-Cyclopropyl-2-{[2-(trifluoromethoxy)phenyl]carbonyl}hydrazinecarboxamide; With sodium hydroxide; In water; for 96h; Reflux;

With hydrogenchloride; In water; pH=10;

Reference yield:

2-(trifluoromethoxy)benzoic acid hydrazide (175277-19-7) → 4-Cyclopropyl-5-[2-(trifluoromethoxy)phenyl]-2,4-dihydro-3H-1,2,4-triazol-3-one (1245940-70-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: tetrahydrofuran / 18 h / 60 °C

2.1: sodium hydroxide / water / 96 h / Reflux

2.2: pH 10

With sodium hydroxide; In tetrahydrofuran; water;

Reference yield:

4-Cyclopropyl-5-[2-(trifluoromethoxy)phenyl]-2,4-dihydro-3H-1,2,4-triazol-3-one (1245940-70-8) + methyl chloroacetate (96-34-4) → Methyl {4-cyclopropyl-5-oxo-3-[2-(trifluoromethoxy)phenyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}acetate (1245940-71-9)

Guidance literature:

With caesium carbonate; In water; acetonitrile; for 2h; Reflux;

upstream raw materials:

2-(trifluoromethoxy)benzoic acid hydrazide

N-Cyclopropyl-2-{[2-(trifluoromethoxy)phenyl]carbonyl}hydrazinecarboxamide

Downstream raw materials:

Methyl {4-cyclopropyl-5-oxo-3-[2-(trifluoromethoxy)phenyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}acetate

{4-Cyclopropyl-5-oxo-3-[2-(trifluoromethoxy)phenyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}acetic acid

2-[({4-Cyclopropyl-5-oxo-3-[2-(trifluoromethoxy)phenyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}acetyl)amino]-2-[3-(trifluoromethyl)phenyl]propanamide

C₂₄H₂₁F₆N₅O₄

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