(1R,2S)-2-Benzyloxy-1-((2S,3S,5S)-5-benzyloxymethyl-3-hydroxy-2-propyl-tetrahydro-furan-2-yl)-propane-1,3-diol

Base Information

Chemical Name:(1R,2S)-2-Benzyloxy-1-((2S,3S,5S)-5-benzyloxymethyl-3-hydroxy-2-propyl-tetrahydro-furan-2-yl)-propane-1,3-diol
CAS No.:871268-76-7
Molecular Formula:C₂₅H₃₄O₆
Molecular Weight:430.541
Hs Code.:

Synonyms:(1R,2S)-2-Benzyloxy-1-((2S,3S,5S)-5-benzyloxymethyl-3-hydroxy-2-propyl-tetrahydro-furan-2-yl)-propane-1,3-diol

Suppliers and Price of (1R,2S)-2-Benzyloxy-1-((2S,3S,5S)-5-benzyloxymethyl-3-hydroxy-2-propyl-tetrahydro-furan-2-yl)-propane-1,3-diol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (1R,2S)-2-Benzyloxy-1-((2S,3S,5S)-5-benzyloxymethyl-3-hydroxy-2-propyl-tetrahydro-furan-2-yl)-propane-1,3-diol

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (1R,2S)-2-Benzyloxy-1-((2S,3S,5S)-5-benzyloxymethyl-3-hydroxy-2-propyl-tetrahydro-furan-2-yl)-propane-1,3-diol

There total 1 articles about (1R,2S)-2-Benzyloxy-1-((2S,3S,5S)-5-benzyloxymethyl-3-hydroxy-2-propyl-tetrahydro-furan-2-yl)-propane-1,3-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: (2R,3S)-3-(Benzhydryl-dimethyl-silanyl)-2-[(1R,2S)-2-benzyloxy-1,3-bis-(tert-butyl-dimethyl-silanyloxy)-propyl]-5-benzyloxymethyl-2-propyl-tetrahydro-furan

: 871268-76-7
(1R,2S)-2-Benzyloxy-1-((2S,3S,5S)-5-benzyloxymethyl-3-hydroxy-2-propyl-tetrahydro-furan-2-yl)-propane-1,3-diol

: (1R,2S)-2-Benzyloxy-1-((2S,3S,5R)-5-benzyloxymethyl-3-hydroxy-2-propyl-tetrahydro-furan-2-yl)-propane-1,3-diol

Guidance literature:: With tert.-butylhydroperoxide; tetrabutyl ammonium fluoride; potassium hydride; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; decane; at 20 - 50 ℃;
DOI:10.1021/ol052321r

Reference yield: 91.0%

: 871268-76-7
(1R,2S)-2-Benzyloxy-1-((2S,3S,5S)-5-benzyloxymethyl-3-hydroxy-2-propyl-tetrahydro-furan-2-yl)-propane-1,3-diol

: 18162-48-6
tert-butyldimethylsilyl chloride

: 871268-77-8
(1R,2S)-2-Benzyloxy-1-[(2R,3S,5S)-5-benzyloxymethyl-3-(tert-butyl-dimethyl-silanyloxy)-2-propyl-tetrahydro-furan-2-yl]-3-(tert-butyl-dimethyl-silanyloxy)-propan-1-ol

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; at 20 ℃; for 24h;
DOI:10.1021/ol052321r

Reference yield:

: 871268-76-7
(1R,2S)-2-Benzyloxy-1-((2S,3S,5S)-5-benzyloxymethyl-3-hydroxy-2-propyl-tetrahydro-furan-2-yl)-propane-1,3-diol

: 871268-86-9
3-((1S,2R,3S,4R,5R,7R)-3-Benzyloxy-8-oxo-5-propyl-2-triethylsilanyloxy-4-triisopropylsilanyloxy-6-oxa-bicyclo[3.2.1]oct-7-yl)-propionaldehyde

Guidance literature:: Multi-step reaction with 10 steps

1: 91 percent / imidazole / dimethylformamide / 24 h / 20 °C

2: 99 percent / 2,6-lutidine / CH₂Cl₂ / 0 - 20 °C

3: 81 percent / p-TsOH*H₂O / methanol / 0 - 20 °C

4: DMSO; oxalyl chloride; triethylamine / CH₂Cl₂ / -50 - 20 °C

5: 46 percent / Na₂CO₃*10H₂O / tetrahydrofuran; methanol; H₂O / 1 h / 20 °C

6: 97 percent / imidazole / CH₂Cl₂ / 0.5 h / 20 °C

7: 99 percent / H₂ / Pd/C / ethanol / 36 h / 20 °C / 760 Torr

8: DMSO; oxalyl chloride; triethylamine / CH₂Cl₂ / -78 - 20 °C

9: 154 mg / CH₂Cl₂ / 0.5 h / 20 °C

10: 79 percent / H₂ / Pd/C / ethyl acetate; ethanol / 2 h / 20 °C / 760 Torr

With 1H-imidazole; 2,6-dimethylpyridine; oxalyl dichloride; hydrogen; sodium carbonate; toluene-4-sulfonic acid; dimethyl sulfoxide; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; 4: Swern oxidation / 8: Swern oxidation;
DOI:10.1021/ol052321r