1-[5-chloro-2-(2-ethyl-butoxy)-benzyl]-1H-pyrazole-4-carboxylic acid ethyl ester

Base Information

Chemical Name:1-[5-chloro-2-(2-ethyl-butoxy)-benzyl]-1H-pyrazole-4-carboxylic acid ethyl ester
CAS No.:1444368-32-4
Molecular Formula:C₁₉H₂₅ClN₂O₃
Molecular Weight:364.872
Hs Code.:

Synonyms:1-[5-chloro-2-(2-ethyl-butoxy)-benzyl]-1H-pyrazole-4-carboxylic acid ethyl ester

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Chemical Property of 1-[5-chloro-2-(2-ethyl-butoxy)-benzyl]-1H-pyrazole-4-carboxylic acid ethyl ester

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Technology Process of 1-[5-chloro-2-(2-ethyl-butoxy)-benzyl]-1H-pyrazole-4-carboxylic acid ethyl ester

There total 4 articles about 1-[5-chloro-2-(2-ethyl-butoxy)-benzyl]-1H-pyrazole-4-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 37622-90-5
4-ethoxycarbonylpyrazole

: 1444368-28-8
methanesulfonic acid 5-chloro-2-(2-ethyl-butoxy)-benzyl ester

: 1444368-32-4
1-[5-chloro-2-(2-ethyl-butoxy)-benzyl]-1H-pyrazole-4-carboxylic acid ethyl ester

Guidance literature:: 4-ethoxycarbonylpyrazole; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 0.5h; Inert atmosphere;

methanesulfonic acid 5-chloro-2-(2-ethyl-butoxy)-benzyl ester; In N,N-dimethyl-formamide; mineral oil; for 16h;

Reference yield:

: 1444368-20-0
5-chloro-2-(2-ethyl-butoxy)-benzaldehyde

: 1444368-32-4
1-[5-chloro-2-(2-ethyl-butoxy)-benzyl]-1H-pyrazole-4-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium tetrahydroborate / methanol / 2 h / 5 - 20 °C / Inert atmosphere

2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 20 °C / Inert atmosphere

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 20 °C / Inert atmosphere

3.2: 16 h

With sodium tetrahydroborate; sodium hydride; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 635-93-8
5-chlorosalicyclaldehyde

: 1444368-32-4
1-[5-chloro-2-(2-ethyl-butoxy)-benzyl]-1H-pyrazole-4-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate; tetra-(n-butyl)ammonium iodide / N,N-dimethyl-formamide / 5 h / 120 °C / Inert atmosphere

2.1: sodium tetrahydroborate / methanol / 2 h / 5 - 20 °C / Inert atmosphere

3.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 20 °C / Inert atmosphere

4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 20 °C / Inert atmosphere

4.2: 16 h

With sodium tetrahydroborate; tetra-(n-butyl)ammonium iodide; sodium hydride; potassium carbonate; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane; N,N-dimethyl-formamide; mineral oil;