6-Fluor-9-(4-fluorphenyl)-2,3,4,9-tetrahydro-2-phenylmethyl-1H-pyrido<3,4-b>indol

Base Information

Chemical Name:6-Fluor-9-(4-fluorphenyl)-2,3,4,9-tetrahydro-2-phenylmethyl-1H-pyrido<3,4-b>indol
CAS No.:154770-66-8
Molecular Formula:C₂₄H₂₀F₂N₂
Molecular Weight:374.433
Hs Code.:

Synonyms:6-Fluor-9-(4-fluorphenyl)-2,3,4,9-tetrahydro-2-phenylmethyl-1H-pyrido<3,4-b>indol

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Chemical Property of 6-Fluor-9-(4-fluorphenyl)-2,3,4,9-tetrahydro-2-phenylmethyl-1H-pyrido<3,4-b>indol

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Technology Process of 6-Fluor-9-(4-fluorphenyl)-2,3,4,9-tetrahydro-2-phenylmethyl-1H-pyrido<3,4-b>indol

There total 5 articles about 6-Fluor-9-(4-fluorphenyl)-2,3,4,9-tetrahydro-2-phenylmethyl-1H-pyrido<3,4-b>indol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 154770-65-7
6-Fluoro-2,3,4,9-tetrahydro-2-(phenylmethyl)-1H-pyrido<3,4-b>indole

: 460-00-4
1-Bromo-4-fluorobenzene

: 154770-66-8
6-Fluor-9-(4-fluorphenyl)-2,3,4,9-tetrahydro-2-phenylmethyl-1H-pyrido<3,4-b>indol

Guidance literature:: With 1-methyl-pyrrolidin-2-one; copper(I) bromide; sodium carbonate; at 185 - 195 ℃; for 8h;
DOI:10.1002/ardp.19933261206

Reference yield:

: 111492-84-3
6-Fluoro-2,3,4,9-tetrahydro-2-(phenylmethyl)-1H-pyrido<3,4-b>indol-1-one

: 154770-66-8
6-Fluor-9-(4-fluorphenyl)-2,3,4,9-tetrahydro-2-phenylmethyl-1H-pyrido<3,4-b>indol

Guidance literature:: Multi-step reaction with 2 steps

1: 93 percent / LiAlH₄ / tetrahydrofuran / 1.) r.t., 30 min, 2.) reflux, 3 h

2: 45 percent / Cu₂Br₂, Na₂CO₃, N-methylpyrrolidone-2 / 8 h / 185 - 195 °C

With 1-methyl-pyrrolidin-2-one; copper(I) bromide; lithium aluminium tetrahydride; sodium carbonate; In tetrahydrofuran;
DOI:10.1002/ardp.19933261206

Reference yield:

: 110977-75-8
3-(4-Fluorphenylhydrazono)-5,6-dihydro-pyran-2(4H)-on

: 154770-66-8
6-Fluor-9-(4-fluorphenyl)-2,3,4,9-tetrahydro-2-phenylmethyl-1H-pyrido<3,4-b>indol

Guidance literature:: Multi-step reaction with 4 steps

1: 89 percent / 5percent HCl / acetic acid / 0.17 h / Heating

2: 83 percent / 8 h / 205 - 210 °C

3: 93 percent / LiAlH₄ / tetrahydrofuran / 1.) r.t., 30 min, 2.) reflux, 3 h

4: 45 percent / Cu₂Br₂, Na₂CO₃, N-methylpyrrolidone-2 / 8 h / 185 - 195 °C

With 1-methyl-pyrrolidin-2-one; copper(I) bromide; hydrogenchloride; lithium aluminium tetrahydride; sodium carbonate; In tetrahydrofuran; acetic acid;
DOI:10.1002/ardp.19933261206